Telomeres, Aging, and Nutrients
Objective: The objective was to examine whether multivitamin use is associated with longer telomeres in women.
Design: We performed a cross-sectional analysis of data from 586 early participants (age 35–74 y) in the Sister Study. Multivitamin use and nutrient intakes were assessed with a 146-item food-frequency questionnaire, and relative telomere length of leukocyte DNA was measured by quantitative polymerase chain reaction.
Results: After age and other potential confounders were adjusted for, multivitamin use was associated with longer telomeres. Compared with nonusers, the relative telomere length of leukocyte DNA was on average 5.1% longer among daily multivitamin users (P for trend = 0.002). In the analysis of micronutrients, higher intakes of vitamins C and E from foods were each associated with longer telomeres, even after adjustment for multivitamin use. Furthermore, intakes of both nutrients were associated with telomere length among women who did not take multivitamins.
Conclusion: This study provides the first epidemiologic evidence that multivitamin use is associated with longer telomere length among women.
Qun Xu, Christine G Parks, Lisa A DeRoo, Richard M Cawthon, Dale P Sandler and Honglei Chen.
Multivitamin use and telomere length in women
Am J Clin Nutr
Epidemiology Branch, National Institute for Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC.