HEALTH NEWS
Super Stars for Gut-Brain Axis Health and Vitality
October 13, 2025

The most sophisticated orchestra in your body takes place with the gut microbiome, brain, and vagus nerve. Trillions of gut microbes communicate back and forth to the brain and vice versa via the vagus nerves, ultimately affecting the functionality of the trillions of cells in the rest of your body. The strength of this super system impacts all aspects of your overall health—from sleep, energy, cognitive health, and mood to vision, hearing, heart, liver, and respiratory function.
Keeping the gut-brain axis healthy requires fundamental support with a nutritious whole foods diet, exercise, stress management, and quality sleep. This system also requires a vast array of nutrients from the basics of protein, vitamins, and minerals to superstar nutrients to help your whole body thrive.
Superstars for gut-brain axis protection include PEA Ultra, Tributyrin Plus, Quercetin Phytosome + Luteolin, and Berberine Ultra. Rooted in traditional healing practices and backed by modern scientific research, these nutrients demonstrate dynamic, whole-body support for a healthy gut-brain axis. We are thrilled to have advanced absorption forms of these nutrients in our product line.
PEA Ultra
PEA has been researched since the 1950’s with worldwide interest due to its critical regulatory effects with brain, gut, and immune system functions.
PEA is a powerful resolving lipid that helps your body clean up all kinds of wear and tear. It supports a healthy, balanced inflammatory response in your brain, gut, and throughout your body. It acts a nootropic or “smart nutrient and supports BDNF production for cognitive function. It inhibits cytokine production and mast cell release of histamine.
PEA regulates the crosstalk between the gut microbiome and immune system which supports a healthier balance of neurochemicals (serotonin, kynurenine). It helps reshape the gut microbiome by promoting Bifidobacterium and other beneficial bacteria which promote butyrate production. It provides essential support for restoration and repair for healthy gut structure, function, brain health, and much more.
PEA Ultra contains 300 mg of Levagen®+ PEA, an advanced form for superior absorption backed by human clinical trials. It has been a very popular addition to our supplement line for comfort and repair for all tissue in your body.
Tributyrin Plus
Butyrate is the primary energy source for intestinal cells, essential for repairing and maintaining the integrity of the gut mucosal lining. Butyrate is the most common short chain fatty acid (SCFA) in your GI tract. Along with other SCFAs, it affects countless functions involving the gut-brain axis, immune system, circadian rhythms, cognitive function, mood and stress tolerance, neurotransmitter production, cortisol metabolism, mitochondrial activities and more. SCFAs also influence fat and glucose metabolism as they are natural GLP-1 inhibitors.
Butyrate production depends on healthy gut microbiome and dietary fibers. The Western Diet lacks adequate fiber which diminishes SCFA production. Furthermore, imbalanced gut flora and increased intestinal permeability are common results of poor diets, high stress, numerous medications, glyphosate in foods, gluten, and other factors—making it especially important to support healthy butyrate levels.
Tributyrin Plus contains advanced absorption butyrate with prebiotic fibers. This combination enhances its ability to get to the intestinal tract for a healthier gut lining and microbiome and all the downstream metabolic effects for the rest of your body. It is a game changer for gut and brain health and overall metabolic functions!
Quercetin Phytosome + Luteolin
Quercetin is a long-standing bioflavonoid favorite for immune, gut, brain, heart, skin, respiratory health and more. Its antioxidant and immune modulating effects support healthy gut microbiome diversity and balance and protect intestinal barrier lining integrity.
Quercetin8 provides powerful antioxidant and neuroprotective support for the brain while helping regulate neurotransmitter production. During periods of chronic psychological stress or dietary stress from food toxins like MSG, quercetin has been shown to protect brain health and promote a balanced gut microbiome simultaneously.
Research shows that quercetin also supports mood, cognition, metabolism, and energy by regulating several metabolic pathways including coenzyme A (CoA) biosynthesis, gluconeogenesis/glycolysis, the pentose phosphate pathway, and sphingolipid metabolism.
Luteolin, another prized flavonoid, can pass directly into the brain where it provides antioxidant protection and promotes a healthy inflammatory response and insulin sensitivity with glucose metabolism. Luteolin also promotes neuroprotection against chronic stress. It helps balance cortisol and inhibits NF-kappa B and various cytokines.
In the gastrointestinal tract, luteolin supports gut microbiome diversity and beneficial bacteria. It supports repair of the intestinal barrier structure and increases the production of phosphatidylcholine for other gut-brain-liver support. Luteolin and quercetin furthermore inhibit mast cell release of histamine.
Quercetin Phytosome + Luteolin features a phospholipid delivery system for 20x higher bioavailability of quercetin than standard quercetin. We add luteolin to this formula for powerful synergistic support for gut-brain axis, immune, and histamine response. It is a stellar duo for superior protection!
Berberine Ultra
Berberine has been used for more than 1000 years in traditional herbal formulas with great efficacy and health results. Today, research demonstrates berberine’s wide array of benefits. Berberine has important antioxidant activities and has neuroprotective and heart protective effects. It helps regulate key cellular receptors involved with LDL, insulin, AMPK, and energy (ATP). It supports healthy metabolism and function in the liver, kidneys, muscles, lungs, brain, heart, pancreas, and fat cells.
Berberine can enrich the beneficial bacteria population in the gut microbiome which helps improve butyrate production and protects intestinal barrier integrity. In the brain, it has been shown to inhibit microglial activation and helps clear and protect brain cells from metabolic waste. Research shows that berberine protects the brain and gut health on multiple levels.
Wellness Resources Berberine Ultra™ contains Berbevis® Berberine Phytosome™, a great advancement in berberine supplementation. This form of berberine solves the problem of poor absorption that characterizes the standard extract. A single 550mg capsule of Berberine Ultra™ shows four times better bioavailability compared to 500mg of Berberine HCl.
Taking care of your gut-brain axis is one of the most important things you can do for your health. It affects every aspect of your physiology. No matter your age, if you have noticed brain fog, forgetfulness, moodiness, stress, upset stomach, indigestion, bloating, or slower metabolism, consider these nutritional superstars to help restore your vitality and wellbeing.
Additional Resources
The Power of PEA: Feel Better, Think Sharper, Sleep Deeper
PEA Ultra: A Revolutionary Nutrient for Health and Repair
Butyrate Aids Digestive Tract Health: Discover New Tributyrin Plus
Revitalize Your Gut: How Prebiotics, Probiotics & Postbiotics Work Together
Berberine Supports Cholesterol, Neuroprotection, Butyrate and Gut Health
Quercetin Phytosome + Luteolin: Dynamic Duo for Immune Health and Longevity
Supplements to Boost GLP-1 Naturally
Vagus Nerve Vitality: Calming Stress and Restoring Gut Health