Study Title:

Acquired flucytosine resistance during combination of caspofungin and flucytosine for Candida glabra

Study Abstract

Treatment of Candida glabrata cystitis remains a therapeutic challenge and antifungal combination using flucytosine is one option. We describe 2 patients with refractory C. glabrata cystitis who failed flucytosine combined with caspofungin with early-acquired high-level resistance to flucytosine due to nonsense mutations in the FUR1 gene. Rapid acquired flucytosine resistance with microbiological failure should discourage combination of caspofungin and flucytosine during urinary candidiasis.

Copyright © 2015, American Society for Microbiology. All Rights Reserved.

Study Information


Acquired flucytosine resistance during combination of caspofungin and flucytosine for Candida glabrata cystitis
Antimicrob Agents Chemother.
2015 November

Full Study

http://www.ncbi.nlm.nih.gov/pubmed/26525799