Study Title:

Vitamin C in the critically ill - indications and controversies.

Study Abstract

Ascorbic acid (vitamin C) elicits pleiotropic effects in the body. Among its functions, it serves as a potent anti-oxidant, a co-factor in collagen and catecholamine synthesis, and a modulator of immune cell biology. Furthermore, an increasing body of evidence suggests that high-dose vitamin C administration improves hemodynamics, end-organ function, and may improve survival in critically ill patients. This article reviews studies that evaluate vitamin C in pre-clinical models and clinical trials with respect to its therapeutic potential.

Study Information

World J Crit Care Med. 2018 Oct 16;7(5):52-61. doi: 10.5492/wjccm.v7.i5.52. eCollection 2018 Oct 16.

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