Translational Perspective: Is Cinnamon a Suitable Agent for Cognitive Impairment and Alzheimer's Disease Associated With Brain Trauma?
Cinnamon, is an exotic spice and a major constituent of our food which is commonly used in different areas of the world for the treatment of various diseases (Kawatra et al., 2015). Besides its anti-inflammatory, anti-diabetic and anti-cancer properties, cinnamon also exerts strong brain protective and pro-cognitive effects in various models of neurodegeneration (Kawatra et al., 2015; Kelestemur et al., 2016) [Figure 1]. Traumatic brain injury (TBI) is characterized with significant vascular, neuronal and axonal damage that is associated with critical oxidative injury and neuroinflammation (Kelestemur et al., 2016). Clinical studies have already conferred that pre and post-injury systemic inflammation could modify the subsequent prognosis of brain injury (Yulug et al., 2018). Moreover, many pharmacological agents were failed to show a clinical neuroprotective effect after TBI suggesting that there is an emergency need for novel brain protective therapeutic strategies to improve the clinical outcomes. However, although there are increasing promising experimental data, many clinical trials were failed to change the clinical endpoint after TBI (Kelestemur et al., 2016; Yulug et al., 2018). Additionally, studies have already indicated that drug-drug interactions play an essential role in the development of pharmacotoxic side effects (Yulug et al., 2018). Taken together, these findings might further indicate that a single agent which is acting on multiple cell death pathways may exert a higher neuroprotective activity. Here, cinnamon might be a novel clinical candidate agent for TBI with its multifaceted neuroprotective and procognitive effects, and its superior safety profile. Interestingly, it has been recently revealed that brain trauma has been not only associated with cognitive impairment but also increase the risk of the development of Alzheimer’s disease (Cristoforti and Levin, 2015; Kawatra et al., 2015; Kelestemur et al., 2016; Yulug et al., 2018).
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Neural Regen Res . 2019 Aug;14(8):1372-1373. doi: 10.4103/1673-5374.253518.