Too Much Sleep and Diabetes Risk
Methods: 522 individuals (aged 40-64 years) were randomly allocated either to intensive diet-exercise counseling group or control group. Diabetes incidence during follow-up was calculated according to sleep duration at baseline. Sleep duration was obtained for 24 h period. Physical activity, dietary intakes, bodyweight and immune mediators (CRP, IL-6) were measured.
Results: Interaction between sleep duration and treatment group was statistically significant (p=0.003). In the control group, the adjusted hazard ratios with 95% CI for diabetes were 2.29 (1.38-3.80) and 2.74 (1.67-4.50) in the sleep duration groups 9-9.5 h and ≥10h, respectively, compared with that of 7-8.5 hours. In contrast, sleep duration did not influence the incidence of diabetes in the intervention group; for sleep duration groups 9-9.5 h and ≥10 h, the adjusted hazard ratios with 95% CI were 1.10 (0.60-2.01) and 0.73 (0.34-1.56), respectively, compared with that in the reference group (7-8.5 h sleep). Lifestyle intervention resulted in similar improvement in body weight, insulin sensitivity and immune mediator levels regardless of sleep duration.
Conclusion: Long sleep duration is associated with increased type 2 diabetes risk. Lifestyle intervention aiming at weight reduction, healthy diet and increased physical activity may ameliorate some of this excess risk.
Henri Tuomilehto, Markku Peltonen, Markku Partinen, Gilles Lavigne, Johan G Eriksson, Christian Herder, Sirkka Aunola, Sirkka Keinänen-Kiukaanniemi, Pirjo Ilanne-Parikka, Matti Uusitupa, Jaakko Tuomilehto, Jaana Lindström.
SLEEP DURATION, LIFESTYLE INTERVENTION AND INCIDENCE OF TYPE 2 DIABETES IN IMPAIRED GLUCOSE TOLERANCE. THE FINNISH DIABETES PREVENTION STUDY.
Finnish Diabetes Prevention Study Group