Study Title:

Too Much Sleep and Diabetes Risk

Study Abstract

Objective: Both short and long sleep duration have frequently been found to be associated with an increased risk for diabetes. The aim of the present exploratory analysis was to examine the association between sleep duration and type 2 diabetes after lifestyle intervention in overweight people with impaired glucose tolerance in a 7-year prospective follow-up.

Methods: 522 individuals (aged 40-64 years) were randomly allocated either to intensive diet-exercise counseling group or control group. Diabetes incidence during follow-up was calculated according to sleep duration at baseline. Sleep duration was obtained for 24 h period. Physical activity, dietary intakes, bodyweight and immune mediators (CRP, IL-6) were measured.

Results: Interaction between sleep duration and treatment group was statistically significant (p=0.003). In the control group, the adjusted hazard ratios with 95% CI for diabetes were 2.29 (1.38-3.80) and 2.74 (1.67-4.50) in the sleep duration groups 9-9.5 h and ≥10h, respectively, compared with that of 7-8.5 hours. In contrast, sleep duration did not influence the incidence of diabetes in the intervention group; for sleep duration groups 9-9.5 h and ≥10 h, the adjusted hazard ratios with 95% CI were 1.10 (0.60-2.01) and 0.73 (0.34-1.56), respectively, compared with that in the reference group (7-8.5 h sleep). Lifestyle intervention resulted in similar improvement in body weight, insulin sensitivity and immune mediator levels regardless of sleep duration.

Conclusion: Long sleep duration is associated with increased type 2 diabetes risk. Lifestyle intervention aiming at weight reduction, healthy diet and increased physical activity may ameliorate some of this excess risk.

Study Information

Henri Tuomilehto, Markku Peltonen, Markku Partinen, Gilles Lavigne, Johan G Eriksson, Christian Herder, Sirkka Aunola, Sirkka Keinänen-Kiukaanniemi, Pirjo Ilanne-Parikka, Matti Uusitupa, Jaakko Tuomilehto, Jaana Lindström.
SLEEP DURATION, LIFESTYLE INTERVENTION AND INCIDENCE OF TYPE 2 DIABETES IN IMPAIRED GLUCOSE TOLERANCE. THE FINNISH DIABETES PREVENTION STUDY.
Diabetes Care
2009 August
Finnish Diabetes Prevention Study Group

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