Tocotrineols and Vaccine Effectiveness
Results:The results from the clinical trial showed that TRF supplementation significantly increased the total vitamin E level in the plasma of the TRF-supplemented volunteers compared with the placebo group, indicating overall compliance. Volunteers supplemented with TRF showed a significantly (P<0.05) enhanced production of interferon-γ and interleukin (IL)-4 by the mitogen or TT-stimulated leukocytes compared with the control group. Volunteers from the TRF group produced significantly (P<0.05) lower amounts of IL-6 compared with the placebo group. Anti-TT IgG production was also significantly (P<0.05) augmented in the TRF-supplemented group compared with the placebo group.Conclusions:We conclude that TRF has immunostimulatory effects and potential clinical benefits to enhance immune response to vaccines
Mahalingam D, Radhakrishnan AK, Amom Z, Ibrahim N, Nesaretnam K.
Effects of supplementation with tocotrienol-rich fraction on immune response to tetanus toxoid immunization in normal healthy volunteers.
Eur J Clin Nutr.
Malaysian Palm Oil Board, Selangor, Malaysia  International Medical University, Kuala Lumpur, Malaysia.