Study Title:

Sedentary lifestyle and its relation to cardiovascular risk factors and insulin resistance

Study Abstract

INTRODUCTION AND OBJECTIVES:
To analyze the association between sitting time and biomarkers of insulin resistance and inflammation in a sample of healthy male workers.
METHODS:
Cross-sectional study carried out in a sample of 929 volunteers belonging to the Aragon Workers' Health Study cohort. Sociodemographic, anthropometric, pharmacological and laboratory data were collected: lipids-total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, apolipoproteins A-1 and B-100, lipoprotein (a)-, insulin resistance-glucose, glycated hemoglobin, homeostasis model assessment of insulin resistance, insulin, and triglyceride/high-density lipoprotein cholesterol ratio-, and inflammatory profile-C-reactive protein and leukocytes. Information on sitting time and physical activity was assessed using a questionnaire. Sedentary behavior was analyzed in terms of prevalences and medians, according to tertiles, using a multivariate model (crude and adjusted linear regression) with biomarkers of inflammation and insulin resistance.
RESULTS:
The most sedentary individuals had higher body mass index, greater waist circumference, and higher systolic blood pressure, with a significant upward trend in each tertile. Likewise, they had a worse lipid profile with a higher C-reactive protein level, homeostasis model assessment of insulin resistance index, triglyceride/high-density lipoprotein cholesterol ratio, and insulin concentration. In the multivariate analysis, we observed a significant association between the latter parameters and sitting time in hours (log C-reactive protein [β = 0.07], log homeostasis model assessment of insulin resistance index [β = 0.05], triglyceride/high-density lipoprotein cholesterol ratio [β = 0.23], and insulin [β = 0.44]), which remained after adjustment for metabolic equivalents-h/week.
CONCLUSIONS:
Workers who spend more time sitting show a worse inflammatory and insulin resistance profile independently of the physical activity performed.

Study Information

León-Latre M, Moreno-Franco B, Andrés-Esteban EM, Ledesma M, Laclaustra M, Alcalde V, Peñalvo JL, Ordovás JM, Casasnovas JA; Aragon Workers’ Health Study investigators.
Sedentary lifestyle and its relation to cardiovascular risk factors, insulin resistance and inflammatory profile.
Rev Esp Cardiol (Engl Ed).
2014 June

Full Study

http://www.ncbi.nlm.nih.gov/pubmed/24863593