A flavonoid fraction (XE) extracted from the bark of pterocarpus marsupium Roxb. (Leguminoceae) was studied for the hypoglycaemic activity normal and alloxanised albino rats. The drug XE did not show a consistent effect on normal blood sugar levels but it effectively reversed the alloxan-induced changes in the blood sugar level and the beta-cell population in the pancreas. It also showed a protective effect when it was given prior to alloxan administration. The novel action of drug on the pancreatic beta-cells and absence of acute toxicity may offer a new hope to the diabetics in future.
BK Chakravarthy, Gupta Saroj, SS Gambhir, KD Gode. Pancreatic beta cell regeneration – a novel antidiabetic mechanism of Pterocarpus marsupium roxb India Journal of Pharmacology 1980 December