Oregano Oil and Autoimmune Arthritis
METHODS:: Stress protein expression was manipulated in vivo and in vitro with a food component, and immune recognition of stress proteins was studied. RESULTS:: We report that carvacrol, a major compound in oil of many Origanum species, had an unprecedented capacity to co-induce cellular HSP70 expression in vitro and, upon intragastric administration, in Peyer's patches of mice in vivo. As a consequence, carvacrol specifically promoted T cell recognition of endogenous HSP70 as shown in vitro by the activation of an HSP70-specific T cell hybridoma and amplified T cell responses to HSP70 in vivo. Carvacrol administration also increased the number of CD4(+)CD25(+)Foxp3(+) T cells, systemically in the spleen and locally in the joint, and almost completely suppressed proteoglycan-induced experimental arthritis. Furthermore, protection against arthritis could be transferred with T cells isolated from carvacrol-fed mice.
CONCLUSION:: These findings illustrate that a food component can boost protective T cell responses to a self-stress protein and down-regulate inflammatory disease; the immune system responds to one's diet.
Wieten L, van der Zee R, Spiering R, Wagenaar-Hilbers J, van Kooten P, Broere F, van Eden W.
A novel HSP co-inducer boosts stress protein HSP70 to activate T cell regulation of inflammation in autoimmune arthritis
Institute of Infectious Diseases and Immunology, Utrecht University, Utrecht, The Netherlands.