Metformin Use in Children and Adolescents with Prediabetes.
With the increasing incidence of childhood obesity, clinicians need to understand its comorbidities and their management. The American Diabetes Association recommends pediatricians screen high-risk overweight and obese children. Identifying and treating prediabetic children and adolescents can help to reduce the burden of type 2 diabetes. Lifestyle interventions are pivotal. Metformin is the only oral medication approved for diabetes treatment in children. It has been studied in clinical trials in nondiabetic children and has been shown to have beneficial effects on body weight. Effects on diabetes prevention have not been studied and long-term data are limited in the pediatric population.
Pediatr Clin North Am. 2017 Dec;64(6):1341-1353. doi: 10.1016/j.pcl.2017.08.010. Epub 2017 Oct 4. PMID: 29173789.