Male Sex Hormone Levels are Inversely Associated with Aging
Methods: Overall, 1,344 men aged 20-79 years from the population-based cohort Study of Health in Pomerania were followed-up for 5.0 (median) years. We used multivariable regression models to analyze cross-sectional and longitudinal associations of serum sex hormone concentrations (total testosterone [TT], sex hormone-binding globulin [SHBG], calculated free testosterone [free T], and dehydroepiandrosterone sulfate [DHEAS]) with biomarkers of inflammation (fibrinogen, high-sensitive C-reactive protein [hsCRP], and white blood cell count [WBC]) and oxidative stress (γ-glutamyl transferase [GGT]) using ordinary least square (OLS) regression and Generalized Estimating Equations models, respectively.
Results: Cross-sectional models revealed borderline associations of sex hormone concentrations with hsCRP, WBC, and GGT levels that were not retained after multivariable adjustment. Longitudinal multivariable analyses revealed an inverse association between baseline TT, free T, and DHEAS concentrations with change in fibrinogen levels (per SD decrement in TT: 0.25 [95% confidence interval, 0.04-0.45], free T: 0.30 [0.09-0.51], and DHEAS: 0.23 [0.11-0.36]). Furthermore, baseline DHEAS concentrations were inversely associated with change in WBC levels (per SD decrement: 0.53 [0.24-0.82]). Baseline TT, SHBG, free T, and DHEAS concentrations were also inversely associated with change in GGT after multivariable adjustment.
Conclusions: The present study is the first to demonstrate prospective inverse associations between sex hormone concentrations and markers of inflammation and oxidative stress in men. Additional studies are warranted to elucidate potential mechanisms underlying the revealed associations.
Haring R, Baumeister S, Völzke H, Dörr M, Kocher T, Nauck M, Wallaschofski H.
Prospective Inverse Associations of Sex Hormone Concentrations in Men with Biomarkers of Inflammation and Oxidative Stress.
Institute of Clinical Chemistry and Laboratory Medicine, Institute for Community Medicine, Department of Cardiology, Department of Restorative Dentistry, Periodontology and Endodontology; University Medicine Greifswald, Germany.