Magnesium Helps Prevent Bone Loss
METHODS: RANKL and OPG were assessed by immunocytochemistry staining in the tibia for up to 6 months in control rats on regular Mg intake (0.5 g/kg) and experimental rats on reduction of dietary Mg (.04%, 25% and 50% of this Nutrient Requirement).
RESULTS: At all dietary Mg intakes, alteration in the presence of immunocytochemical staining of RANKL and OPG was observed. In general, OPG was decreased and RANKL increased, reflecting an alteration in the RANKL/OPG ratio toward increased osteoclastogenesis.
CONCLUSION: We have, for the first time demonstrated that a reduction in dietary Mg in the rat alters the presence of RANKL and OPG and may explain the increase in osteoclast number and decrease in bone mass in this animal model. As some of these dietary intake reductions in terms of the RDA are present in a large segment of or population, Mg deficiency may be another risk factor for osteoporosis.
Rude RK, Gruber HE, Wei LY, Frausto A.
Immunolocalization of RANKL is increased and OPG decreased during dietary magnesium deficiency in the rat.
Nutr Metab (Lond).
University of Southern California, The Orthopaedic Hospital, GNH 6602, Los Angeles, CA 90089-9317, USA.