Leptin as immune mediator: Interaction between neuroendocrine and immune system.
Leptin is an adipocyte-derived hormone/cytokine that links nutritional status with neuroendocrine and immune functions. Initially described as an anti-obesity hormone, leptin has subsequently been shown to exert pleiotropic effects, being also able to influence haematopoiesis, thermogenesis, reproduction, angiogenesis, and more importantly immune homeostasis. As a cytokine, leptin can affect both innate and adaptive immunity, by inducing a pro-inflammatory response and thus playing a key role in the regulation of the pathogenesis of several autoimmune/inflammatory diseases. In this review, we discuss the most recent advances on the role of leptin as immune-modulator in mammals and we also provide an overview on its main functions in non-mammalian vertebrates. KEYWORDS: Adaptive immunity; Innate immunity; Leptin; Non-mammalian vertebrates
Dev Comp Immunol. 2017 Jan;66:120-129. doi: 10.1016/j.dci.2016.06.006. Epub 2016 Jun 8.