HEALTH NEWS

Study Title:

Grape Seed Extract Lowers Blood Pressure in Metabolic Syndrome

Study Abstract

This study was undertaken to determine whether grape seed extracts (GSE) that contain powerful vasodilator phenolic compounds lower blood pressure in subjects with the metabolic syndrome. The subjects were randomized into 3 groups-(a) placebo, (b) 150 mg GSE per day, and (c) 300 mg GSE per day-and treated for 4 weeks. Serum lipids and blood glucose were measured at the beginning of the study and at the end. Blood pressure was recorded using an ambulatory monitoring device at the start of the treatment period and at the end. Both the systolic and diastolic blood pressures were lowered after treatment with GSE as compared with placebo. There were no significant changes in serum lipids or blood glucose values. These findings suggest that GSE could be used as a nutraceutical in a lifestyle modification program for patients with the metabolic syndrome.

In summary, the present study has demonstrated that an extract of grape seed lowers blood pressure in subjects with the metabolic syndrome. We have shown that the phenolic compounds in the extract are absorbed and that its antioxidant properties could reduce the concentration of Ox-LDL in plasma.

Study Information

Sivaprakasapillai B, Edirisinghe I, Randolph J, Steinberg F, Kappagoda T.
Effect of grape seed extract on blood pressure in subjects with the metabolic syndrome.
Metabolism.
2009 December
Department of Internal Medicine, University of California Davis, Davis, CA 95616, USA.