Fisetin, a potential caloric restriction mimetic, attenuates senescence biomarkers in rat erythrocytes.
An imbalanced redox status is a hallmark of the aging process. Caloric restriction mimetics (CRMs) are compounds that produce caloric restriction benefits at molecular, cellular and physiological levels translating into health-promoting effects. Fisetin is the least explored CRM and its role in modulation of oxidative stress during aging is not clearly known. The present study aims to investigate the anti-oxidative and protective potential of fisetin in D-galactose (D-gal)-induced accelerated senescence model rat and in naturally aged rat erythrocytes. Young rats (4 months), D-gal induced (500 mg/kg b.w., subcutaneously) aging and naturally aged (24 months) rats were supplemented with fisetin (15 mg/kg b.w., orally) for 6 weeks. The data indicated that the supplementation of fisetin suppresses the aging-induced elevation in levels of reactive oxygen species, eryptosis, lipid peroxidation and protein oxidation. Our data also demonstrated that fisetin significantly increases the levels of antioxidants and activates plasma membrane redox system. Taken together, the findings show that fisetin rich diet might be a potential anti-aging intervention strategy.
Biochem Cell Biol. 2019 Jan 9. doi: 10.1139/bcb-2018-0159. [Epub ahead of print]