Study Title:
Fiber and Diabetes Risk
Study Abstract
Aims: To examine the relationship between dietary fiber and risk of type 2 diabetes in older men and the role of hepatic and inflammatory markers.
Methods: A prospective study of 3428 non-diabetic men aged 60-79 years followed up for 7 years, during which there were 162 incident cases of type 2 diabetes.
Results: Low total dietary fiber (lowest quartile;<=20g/day ) was associated with increased risk of diabetes after adjustment for total calorie intake and potential confounders (relative risk, 95% CI −1.47, 1.03-2.11). This increased risk was seen separately for both low cereal and low vegetable fiber intake. Dietary fiber was inversely associated with inflammatory markers (C-reactive protein, interleukin-6 [IL-6]) and with tissue plasminogen activator (t-PA) and gamma-glutamyl transferase (GGT). Adjustment for these markers attenuated the increased risk (1.28 [0.89,1.86]).
Conclusion: Dietary fiber is associated with reduced diabetes risk which may be partly explained by inflammatory markers and hepatic fat deposition.
Methods: A prospective study of 3428 non-diabetic men aged 60-79 years followed up for 7 years, during which there were 162 incident cases of type 2 diabetes.
Results: Low total dietary fiber (lowest quartile;<=20g/day ) was associated with increased risk of diabetes after adjustment for total calorie intake and potential confounders (relative risk, 95% CI −1.47, 1.03-2.11). This increased risk was seen separately for both low cereal and low vegetable fiber intake. Dietary fiber was inversely associated with inflammatory markers (C-reactive protein, interleukin-6 [IL-6]) and with tissue plasminogen activator (t-PA) and gamma-glutamyl transferase (GGT). Adjustment for these markers attenuated the increased risk (1.28 [0.89,1.86]).
Conclusion: Dietary fiber is associated with reduced diabetes risk which may be partly explained by inflammatory markers and hepatic fat deposition.
Study Information
S Goya Wannamethee, Peter H Whincup, Mary Thomas, and Naveed Sattar.
Associations between dietary fiber and inflammation, hepatic function and risk of type 2 diabetes in older men: potential mechanisms for benefits of fiber on diabetes risk.
Diabetes Care
2009 July
Department of Primary Care and Population Health, University College Medical School, Hampstead Campus, London NW3 2PF, UK.
Full Study
