Study Title:

Epstein-Barr virus antibodies and vitamin D in prospective multiple sclerosis biobank samples.

Study Abstract

BACKGROUND:
The antibody reactivity against Epstein-Barr nuclear antigen-1 (EBNA-1), and 25-hydroxyvitamin D (25(OH)D) status have been associated with multiple sclerosis (MS) risk. Interaction between these two factors has been proposed.
OBJECTIVES:
The objective of this paper is to examine the association between antibody reactivity against EBNA-1 and five EBNA-1 domains, and the risk of MS, and to examine if these antibodies and 25(OH)D status interact regarding MS risk in prospectively collected blood samples.
METHODS:
Antibody reactivity and 25(OH)D levels were measured using ELISAs in n = 192 MS cases and n = 384 matched controls. The risk of MS was analysed using matched logistic regression. Interaction on the additive scale was assessed.
RESULTS:
The risk of MS increased across tertiles of antibody reactivity against EBNA-1, domain EBNA-1(402-502), and domain EBNA-1(385-420), p trends < 0.001. In young individuals (below median age at sampling, < 26.4 years), these associations were stronger, and 25(OH)D levels correlated inversely to antibody reactivity against EBNA-1 and the EBNA-1 domains. No statistical interaction was found.
CONCLUSIONS:
We confirm that increased antibody reactivity against EBNA-1 is a risk factor of MS. 25(OH)D status might influence the immune response towards Epstein-Barr virus in young subjects, and thereby modulate MS risk.

Study Information

Salzer J, Nyström M, Hallmans G, Stenlund H, Wadell G, Sundström P.
Epstein-Barr virus antibodies and vitamin D in prospective multiple sclerosis biobank samples.
Mult Scler.
2013 October
Department of Pharmacology and Clinical Neuroscience, Section of Neurology at Umeå University, Sweden.

Full Study

http://www.ncbi.nlm.nih.gov/pubmed/23549431