Study Title:

Cytokine Signaling in Skeletal Muscle Wasting.

Study Abstract

Skeletal muscle wasting occurs in a variety of diseases including diabetes, cancer, Crohn's disease, chronic obstructive pulmonary disease (COPD), disuse, and denervation. Tumor necrosis factor α (TNF-α) is involved in mediating the wasting effect. To date, a causal relationship between TNF-α signaling and muscle wasting has been established in animal models. However, results from clinical trials are conflicting. This is partly due to the fact that other factors such as TNF-like weak inducer of apoptosis (TWEAK) and interleukin 6 (IL-6) are also involved in skeletal muscle wasting. Because muscle wasting is often associated with physical inactivity and reduced food intake, therapeutic interventions will be most effective when multiple approaches are used in conjunction with nutritional support and exercise.
Copyright © 2016 Elsevier Ltd. All rights reserved.
TNF-α; TRAF6; TWEAK; muscle wasting

Study Information

Cytokine Signaling in Skeletal Muscle Wasting.
Trends Endocrinol Metab.
2016 March

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