Circadian clock is associated with tumor microenvironment in kidney renal clear cell carcinoma
Result: A wide range of circadian clock genes are epigenetically altered in KIRC, and associated with the overall survival and disease-free survival of patients. SNV analysis revealed missense mutation and splice site to be the most common variant types of circadian clock genes in KIRC. Several circadian clock genes were involved in the regulation of some cancer-related hallmark pathways, including apoptosis and cell cycle pathway. Further, immune infiltrates analysis not only revealed that the expression of circadian clock genes is associated with immune cell infiltrates, but also that somatic copy-number alteration of circadian clock genes could inhibit the immune infiltrates. Moreover, enrichment analysis implied that the circadian clock genes could regulate transcription factor activity and circadian rhythm in KIRC.
Conclusion: Our results demonstrate the potential of chrono-immunotherapy as a candidate option for the management of KIRC.
Method: Multi-omics analysis was performed to comprehensively determine the roles of core circadian clock genes in KIRC.
Aging (Albany NY) . 2020 Jul 18;12(14):14620-14632. doi: 10.18632/aging.103509. Epub 2020 Jul 18.