Study Title:

Cholesterol metabolism in pathogenesis of osteoarthritis disease.

Study Abstract

Several lines of research indicate that osteoarthritis (OA) is not only a joint disorder associated with mechanical stress and aging but also a 'metabolic syndrome' in which several risk factors work together to contribute to disease initiation and/or development. One such metabolic risk factor could be high cholesterol levels in the body. Even though high cholesterol level is a well-known risk factor for cardiovascular disorders, its possible role in musculoskeletal diseases, particularly OA, is not clear. The authors discuss the fundamental viewpoints on cholesterol involvement in the pathogenesis of OA, stressing the need for understanding the molecular mechanisms behind this association. This is the area of research needed to provide knowledge on how one should live to prevent OA development as well as to suggest new targets for drug therapy.

cholesterol; mitochondria; osteoarthritis; oxidative stress and cartilage

Study Information

Int J Rheum Dis. 2017 Feb;20(2):131-140. doi: 10.1111/1756-185X.13061. Epub 2017 Apr 5.

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