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Study Title:
Association between thyroid dysfunction and dysglycaemia: a prospective cohort study.
Study Abstract
Abstract:
AIMS:
To compare the incidence of hyperglycaemia among participants with low, elevated and normal serum thyroid-stimulating hormone concentration, as well as the incidence of abnormal thyroid function test results among participants with normal blood glucose and those with hyperglycaemia.METHODS:
In a prospective study, a cohort of 72 003 participants with normal, low and elevated serum thyroid-stimulating hormone concentration were followed from the study beginning to the first report of diabetes and prediabetes. A proportional hazards regression model was used to calculate the hazard ratios and 95% CIs for each outcome, adjusting for age, sex, education level, smoking, alcohol consumption and obesity. Analyses for the association between dysglycaemia and incident abnormal thyroid function test were also conducted.RESULTS:
During a median 2.6 year follow-up, the incident rates for dysglycaemia, particularly prediabetes, were substantially higher in participants with elevated thyroid-stimulating hormone concentrations at baseline, while the rates for participants with normal and low thyroid-stimulating hormone were similar. After controlling for risk factors, participants with elevated thyroid-stimulating hormone retained a 15% increase in risk of prediabetes (adjusted hazard ratio 1.16, 95% CI 1.05-1.28), but were not at greater risk of diabetes (adjusted hazard ratio 1.04, 95% CI 0.68-1.52). By contrast, participants with normal and low thyroid-stimulating hormone concentrations had similar dysglycaemia risks. Participants with diabetes and prediabetes were not at greater risks of developing abnormal thyroid function test results when compared with participants with euglycaemia.CONCLUSIONS:
People with elevated serum thyroid-stimulating hormone concentration are at greater risk of developing prediabetes. Whether this includes a greater risk of developing frank diabetes may require an extended period of follow-up to clarify. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved. Study Information: Chang CH1,2,3, Yeh YC1, Shih SR2,3, Lin JW2,3,4, Chuang LM1,2,3, Caffrey JL5, Tu YK1. Diabet Med. 2017 Jul 14. Fully Study: https://www.ncbi.nlm.nih.gov/pubmed/28710779