Abstract 13040: Discordance Between Blood Pressure and Endothelial Function Measurements; is it Time to Look Beyond Blood Pressure for Early Detection of CVD Risk?
Methods: A total of 6266 endothelial function test results were collected from 42 outpatient clinics in the US that participated in VENDYS Registry. Blood pressure was measured before each test. The tests were conducted using FDA-approved automated VENDYS devices (Endothelix Inc., Palo Alto, CA). Adjusted maximum temperature rebound was reported as Vascular Reactivity Index (VRI).
Results: Systolic and diastolic blood pressure were 136.6±20.2 and 76±12.4 mmHg respectively. VRI was 1.55±0.53. Neither systolic or diastolic blood pressure showed a strong correlation with VRI. See graphs below. Both VRI and blood pressure (systolic and diastolic) showed a stronger correlation with age r= -0.18, r= 0.17, r=-0.16 respectively, p< 0.0001.
Conclusions: In this 6266 patient registry, endothelial function measured by VRI showed a very weak correlation with blood pressure. Our finding supports previous reports by others, and warrants studies to evaluate the additive value of endothelial function monitoring beyond blood pressure.
Originally published11 Nov 2019Circulation. 2019;140:A13040