[Social isolation during old age worsens cognitive, behavioral and immune impairment]
Material and methods: Twenty female C57b/129sv mice, housed in groups of 4-5 until their old age (18 months), remained in groups (controls, n=10) or were isolated after reaching the age of 18 months and until they reached the age of 24 months (isolated, n=10). At this advanced age, the animals were submitted to a battery of tests to assess neophobia (corner test), anxiety (open-field test), and learning and memory (Morris water maze). Thereafter, the animals were sacrificed and the thymus was removed. The natural killer (NK) activity of the thymic cells against the YAC-1 murine tumor cell line was evaluated.
Results: Animals isolated during old age showed functional and cognitive decline, with increased neophobia and anxiety as well as learning and memory deficits. In addition, isolation reduced the NK activity of thymic cells.
Conclusions: We demonstrate the importance of social isolation and solitude during old age. Both social isolation and solitude exacerbate mental and immunological involution during this period, despite normal social life during previous stages of life.
Rev Esp Geriatr Gerontol . May-Jun 2009;44(3):137-42. doi: 10.1016/j.regg.2008.12.001. Epub 2009 May 8.