Have you ever wondered why you always seem to come down with a cold as soon as finals season rolls around or after a particularly stressful time at work? It all comes down to the fascinating connection between cortisol release and antioxidant levels. Let’s break down the science behind your adrenal glands and antioxidants so you can fortify yourself in the future. 

Adrenal Glands, Cortisol & Antioxidants 

Your adrenal glands, located on top of your kidneys are responsible for producing cortisol, aldosterone, and dehydroepiandrosterone (DHEA).  These adrenal hormones are essential for a healthy stress response. They are also closely linked to the balance of antioxidants and Reactive Oxidative Species (ROS) in the body.

When cortisol production is in excess, the number of Reactive Oxygen Species (ROS) can begin to exceed the amount of antioxidants required to neutralize them.  The over proliferation of ROS (commonly called free radicals) has been shown to cause cellular damage and hasten cellular aging. When there are insufficient antioxidants to fight the higher number of free radicals, it can lead to that run-down feeling in the short-term. Long-term, heightened and prolonged oxidative stress can lead to the development of many acute and chronic diseases.

Higher Levels of Oxidative Stress Can Reduce Your Immunity

Why the close connection between stress and immunity? It all comes down to the inverse relationship between cortisol and antioxidant levels. Excess cortisol release activates the glucocorticoid receptors in cells. This boosts the creation of reactive oxygen species released in the bloodstream. At the same time, it also inhibits antioxidant activity in the body. Furthermore, the activation of MAPK, NF-KB pathways and HPA axis signaling from cortisol release also set off a cascade of complex reactions that lead to increased ROS levels. When free radicals are up and antioxidant levels are down, this imbalance is the root cause of oxidative stress and stress-induced dips in immune function.

Using Vitamin C to Up Antioxidant Levels and Curb Cortisol Production 

What can you do to combat the oxidative stress caused by chronic stress? Eating a balanced whole foods diet rich in micronutrients is an excellent place to start. After that, targeted supplementation with antioxidants like Vitamin C can help.

Vitamin C is an antioxidant that scavenges free radicals. It is also highly concentrated in the cells of your adrenal glands and in the collagenous tissue that makes up endocrine glands and organs. In animal studies, Vitamin C has been shown to positively modulate the body’s stress response by literally pumping the brakes on cortisol production.  Looking for an easy way to nourish your adrenal glands and support your immune system? Our Buffered C Powder or Vitamin C Capsules are a great option.  The Buffered C powder adds essential electrolytes and minerals to aid digestion and offers additional nutritional support with magnesium and calcium. One scoop of our Buffered C powder packs an impressive immune boost, with 2750 mg of Vitamin C and zero added sugar. If you don’t want to mix into beverages or soft foods, our ascorbic acid capsules offer potent antioxidant support in a convenient 1-a-day serving size.

In addition to diet and supplementation, lifestyle interventions can help. Introducing regular gentle exercise, limiting alcohol, avoiding smoking, and finding ways to reduce or cut out sources of stress in your life will all support your adrenal glands to function so you feel balanced and well all year-round. 

References:
Patani, A., Balram, D., Kumar Yadav, V., Lian, K.Y., Patel, A. & Kumar Sahoo, D. (2023). Harnessing the Power of Nutritional Antioxidants Against Adrenal Hormone Imbalance-Associated Oxidative Stress. National Institute of Health, PubMed. PMCID: PMC10720671  PMID: 38098868 https://pmc.ncbi.nlm.nih.gov/articles/PMC10720671/