HEALTH NEWS

The Power of PEA: Feel Better, Think Sharper, Sleep Deeper

By Dr. Linda J. Dobberstein, DC, Board Certified in Clinical Nutrition

May 19, 2025

The Power of PEA: Feel Better, Think Sharper, Sleep Deeper

PEA (Palmitoylethanolamide) is a naturally occurring lipid that plays a critical role in supporting a healthy inflammatory response, cellular repair, and overall well-being. As modern life bombards us with physical, environmental, and emotional stressors, we face an increased demand for nutrients that help restore balance. PEA stands out as an essential compound that helps offset these stress repair responses, supporting your whole body especially nervous, immune, and musculoskeletal system.

PEA and Your Stress Response

PEA supports healthy cellular function and overall balance. It belongs to a group of fats called bioactive lipids that play an important role in how cells communicate, respond and resolve daily cellular stressors.

PEA is produced in small amounts by the body daily with increased amounts needed during times of stress to help regulate immune activity, pain signaling, and homeostasis. However, modern day stressors, aging, and nutrient-deficient diets can deplete PEA stores faster than the body can replenish them. The demand for PEA increases in response. Supplementing PEA offers an effective way to restore balance, enhance recovery, and support long-term health.

PEA for Nerves, Repair, Immune, and Cellular Health

PEA works through several key systems in the body to allow clean up and repair mechanisms to resolve their activities rather than linger. It provides immense support for immune health, nerve function, repair, and cellular signaling.

PEA helps regulate important biological pathways and compounds, such as PPAR-alpha, mast cells and histamine, cytokines, and Cox-2, and supports the activity of immune cells to help the body maintain a stable, balanced state. PEA is a fastidious housekeeper of your body.

By supporting these core functions, PEA helps your body respond more effectively to internal and external challenges, promoting long-term health and resilience.

Scientific studies have shown that PEA:

Supports faster, more complete muscle recovery from exercise and daily activity

Promotes quicker sleep onset and mental clarity upon waking

Enhances cognitive performance and mental focus (considered a nootropic or “smart nutrient”)

Increases muscle power and strength when combined with resistance training

Helps alleviate minor pain and modulate pain receptor sites

Supports a healthy, balanced inflammation response

Aids immune system resilience and recovery

Encourages healthy mast cell activity and balanced histamine response

Promotes gut microbiome balance and gut-immune-brain axis health

Aids in protection of gut barrier by inhibiting cytokine production

Supports healthy communication between nerve and glial cells for optimal brain function

Encourages BDNF production for cognitive function

Support mood

Promotes joint comfort and mobility

PEA for Women’s Health and Metabolism

A 2024 clinical trial demonstrated the benefits of PEA in post-menopausal women. Results showed that PEA promoted the browning of white adipose tissue, which supports healthy weight management and cholesterol metabolism. Additionally, the study noted improved insulin signaling, leptin sensitivity, and appetite regulation.

Another clinical trial reported improved comfort and tolerance during the menstrual cycle. Participants took 300-600 mg of PEA daily and saw noticeable improvements.

Modern Life Increases PEA Demand

Although PEA is made by the body its production can decline as stress rises. This is especially true in the context of today’s physical, emotional, and environmental stressors. Supplementing with PEA helps restore tissue levels and supports balance.

Optimizing recovery and repair also requires proper overall nutrition. A diet rich in organic whole foods, at least 80-90% of the time, helps maintain nutritional reserves. Reducing exposure to toxins and cutting out unhealthy habits can also reduce your body’s burden. If you find yourself longing for the energy and resiliency of your youth, PEA Ultra is an excellent choice to add to your daily routine! 

While PEA is present in small amounts in potatoes, tomatoes, the seeds of peas and beans with higher concentrations in human breastmilk and cow’s milk, supplementation remains the most effective way to quickly and efficiently replenish tissue levels and restore cellular homeostasis.

Wellness Resources PEA Ultra delivers 300 mg of Levagen®+ PEA per capsule. This branded form of PEA has been clinically proven to offer superior absorption and bioavailability over standard PEA forms.

Levagen®+ is supported by human clinical trials and is non-GMO, gluten free, allergen free, vegan and free of the World Anti-Doping Agency (WADA) banned substances.

PEA has a calming effect on the brain and helps promote relaxation. When taken at bedtime, it supports deep, restorative sleep. It may also be taken during the day to assist with general recovery from wear and tear. Recommended dosage ranges from 1-4 capsules per day, depending on individual needs.

For best results, take PEA consistently for 3-6 months or longer. Daily usage helps build up tissue reserves and supports healthy aging. PEA has an excellent safety profile and is considered a safe alternative to CBD products, without the risk of THC exposure.

PEA has been studied since the 1950’s and has captured attention worldwide. Has it caught yours? Add this game-changing supplement to your wellness routine to support sleep, repair needs, stress relief, and feel in balance!

Additional resources:

PEA Ultra: A Revolutionary Nutrient for Health and Repair

PEA for Healthy Mast Cell Activity

PEA Effective for Exercise Recovery and Athletes

PEA Calms Digestive Stress and Improves Bowel Motility

PEA: Natural Support for Nerves and Comfort

Is Your Brain on Fire? Stress and Injury Cause Microglial Cell Overactivation

Brain Fog and Irritability Linked to Glial Cell Health

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