Zinc and Immunity

Byron's Comments:

Zinc adequacy is vital for an efficeint immune response.

Study Title:

Zinc transporter ZIP8 (SLC39A8) and zinc influence IFN- expression in activated human T cells.

Study Abstract:

The zinc transporter ZIP8 is highly expressed in T cells derived from human subjects. T cell ZIP8 expression was markedly up-regulated upon in vitro activation. T cells collected from human subjects who had received oral zinc supplementation (15 mg/day) had higher expression of the activation marker IFN- upon in vitro activation, indicating a potentiating effect of zinc on T cell activation. Similarly, in vitro zinc treatment of T cells along with activation resulted in increased IFN- expression with a maximum effect at 3.1 µM. Knockdown of ZIP8 in T cells by siRNA decreased ZIP8 levels in nonactivated and activated cells and concomitantly reduced secretion of IFN- and perforin, both signatures of activation. Overexpression of ZIP8 by transient transfection caused T cells to exhibit enhanced activation. Confocal microscopy established that ZIP8 is localized to the lysosome where ZIP8 abundance is increased upon activation. Loss of lysosomal labile zinc in response to activation was measured by flow cytometry using a zinc fluorophore. Zinc between 0.8 and 3.1 µM reduced CN phosphatase activity. CN was also inhibited by the CN inhibitor FK506 and ZIP8 overexpression. The results suggest that zinc at low concentrations, through inhibition of CN, sustains phosphorylation of the transcription factor CREB, yielding greater IFN- expression in T cells. ZIP8, through control of zinc transport from the lysosome, may provide a secondary level of IFN- regulation in T cells.

From press release:

Everyone knows that vitamins “from A to zinc” are important for good health. Now, a new research study in the August 2009 print issue of the Journal of Leukocyte Biology suggests that zinc may be pointing the way to new therapeutic targets for fighting infections. Specifically, scientists from Florida found that zinc not only supports healthy immune function, but increases activation of the cells (T cells) responsible for destroying viruses and bacteria.

“It has been shown that zinc supplementation significantly reduces the duration and severity of childhood diarrhea, lower respiratory infections, and incidence of malaria in zinc-deficient children,” said report co-author, Robert Cousins, Ph.D., who also is the director of the Center for Nutritional Sciences within the Food Science and Human Nutrition Department at the University of Florida. “Age-related declines in immune function have also been related to zinc deficiency in the elderly.”

Scientists administered either a zinc supplement or a placebo to healthy volunteers to assess the effects of zinc on T cell activation. After isolating the T cells from the blood, scientists then simulated infection in laboratory conditions. Results showed that T cells taken from the zinc-supplemented group had higher activation than those from the placebo group. Specifically, cell activation stimulated the zinc transporter in T cells called “ZIP8,” which transports stored zinc into the cell cytoplasm where it then alters the expression of a T cell protein in a way needed to fight infections.

“As the debate over zinc supplementation in healthy individuals continues,” said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology, “studies like this help shed light on how zinc may enhance the ability of our immune systems to fight off foreign invaders. Equally important, this work points toward new possible targets for entirely new drugs to help augment immune function and prevent or stop infections that might be resistant to traditional antibiotics.”

Study Information:

Tolunay B. Aydemir, Juan P. Liuzzi, Steve McClellan, and Robert J. Cousins. Zinc transporter ZIP8 (SLC39A8) and zinc influence IFN- expression in activated human T cells. Journal of Leukocyte Biology. 2009 August 
Center for Nutritional Sciences, College of Agricultural and Life Sciences,Department of Biochemistry and Molecular Biology, College of Medicine, andInterdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, Florida, USA.

Full Study:

http://www.jleukbio.org/cgi/rapidpdf/jlb.1208759v1


Related Entries: Whiplash, Thyroid, and Adrenals
Brain Inflammation Now Documented in Chronic Fatigue Syndrome
Brain Protective Effects of Proathocyanidins
Nutrient Highlight: Discover the Best Form of Folate
Lutein and Zeaxanthin Offset Gene Weaknesses that Cause Macular Degeneration
Lycopene Builds Its Anti-Prostate Cancer Case
Carotenes Improve the Quality of Semen
Vitamin B12 as Methylcobalamin Repairs Nerves & Lowers Pain
Folic Acid Activates Neural Stem Cells for Brain Rejuvenation
Chromium Improves Insulin Function & Reduces Binge Eating
How Fiber and Niacin Protect Against Colon Inflammation and Cancer
Berries Have Anti-Aging Impact on Immune System
Strawberries Reduce Cardiovascular Risk
Friendly Flora Improves Fatty Liver Disease
Flavonoid Intake Improves Cardio Health in At-Risk Men
Polyphenols and Essential Fatty Acids Reduce Cardio Risk in Overweight People
Vitamin C Reduces the Risk for Hemorrhagic Stroke
Testosterone Therapy Increases Heart Attack Risk
Magnesium Intake Linked to Lower Cardiovascular Inflammation
Q10 Boosts Energy, Nerves, Muscles & Metabolism
Coenzyme Q10 Remarkably Improves Circulation
Tyrosine Helps Maintain Mental Ability Under Stress
Green Tea Extract Lowers Blood Pressure, Cholesterol, Blood Sugar & Inflammation
Poor Flexibility is a Sign of Stiff Arteries
A Sluggish Lymph System Causes Snoring & Sleep Apnea
DHA is Vital to Cardiovascular Wellness
Magnesium Supplements Lower Blood Pressure, Prevent Calcification
Magnesium for the Prevention of Heart Disease
Pomegranate Protects HDL Cholesterol from Damage
Pomegranate Blocks Flu Replication
Tocotrienols:  Twenty Years of Dazzling Cardiovascular and Cancer Research
Is Resveratrol the Fountain of Youth?
Grape Seed Extract Lowers Blood Pressure
Scientists Tout Resveratrol as a Primary Nutrient for Cardio Health
Leptin, Thyroid, and Weight Loss
Excess Appetite Causes Abdominal Fat
Low Energy? Detect Thyroid Related Fatigue
Curcumin Boosts AMPK Activation, Prevents Fatty Liver
Quercetin Activates Mitochondrial Biogenesis
Quercetin Guards Against Inflammation-Induced Bone Loss
Head Injuries Double or Triple the Risk of Early Death
Fatty Fish Consumption Lowers the Risk of Type 2 Diabetes by 33%
Flavonoids Continue to Show Potent Diabetes Prevention
Vitamin K2 Decreases Bone Loss in Postmenopausal Women
Cissus Quadrangularis Enhances Fracture Healing
Cissus Quadrangularis Reduces Exercise-Related Joint Pain
Nobiletin and Tangeretin Help Protect Against Bone Loss
Nobiletin and Tangeretin Inhibit Respiratory Virus
Oregano Oil Inhibits Biofilm Formation
Bromelain Helps Chronic Sinus Inflammation
Curcumin Demonstrates Potent Anti-Flu Properties
Quercetin Protects Brain and Body from Low Oxygen Stress
Ubiquinol Q10 Protects Against Magnified Tissue Injury
Ubiquinol Q10 Protects Eyes of Diabetic Patients
Limonene Promotes Healing of Digestive Lining
Magnesium Intake Reduces Mortality
Fiber is Vital for Cardio Health
Friendly Flora Boosts Weight Loss in Obese Women
Tocotrienols Help Correct Fatty Liver in Humans
Vitamin E Boosts Quality of Life for Alzheimer’s Patients
Astaxanthin Demonstrates Brain Protection & Rejuvenation
Top 10 Health Stories of 2013
Resveratrol’s Amazing Anti-Aging Effect on Circulation
Grape Seed Extract Normalizes Blood Pressure in Mild Hypertension Patients
Don’t Let Bacterial Infections Set Up Shop
Viral Replication Fueled by Sugar
Anti-Vitamin Propaganda Hits a Fever Pitch
Antacid Medications Cause Vitamin B12 Deficiency, Speed Aging
Men Should Take Folic Acid Prior to Conception to Prevent Birth Defects
Exercise Potently Reduces the Risk for Diseases of Aging
Fisetin Demonstrates Potent Bone Protection Properties
Green Tea (EGCG) Improves Body Weight and Autoimmune Arthritis
Low Midlife Iron Contributes to Declining Cognitive Function in Women
DHA Reduces Inflammation in Brains of Alzheimer’s Patients
Low Magnesium Linked to Poor Vitamin D Status
Vitamin D Lowers Depression and Nerve Pain in Women with Type 2 Diabetes
Adequate Vitamin D is Needed to Prevent Brain Damage
Nutrition Makes Anti-Aging Possible: Secrets of Your Telomeres
Acetyl-L-Carnitine and Lipoic Acid Rejuvenate Stressed Mitochondria
Low DHA and EPA Linked to Major Depression and Anxiety
Higher Dose DHA and EPA Reduce Infection Toxins
DHA and EPA Help People with Dry Eye Syndrome
Tocotrienol E Supports Bone Health
Antioxidants and Magnesium Linked to Better Hearing
Bovine Lactoferrin Anti-Flu Properties
Olive Leaf Extract Improves Blood Sugar Metabolism
Bovine Colostrum’s Potent Immune-Support Activity
EPA and DHA Boost Mental Health Scores in Healthy Adults
DHA and EPA Boost Brain Function in Children with ADHD
Chlorella Reduces Red Blood Cell Damage Linked to Cognitive Decline
Aerobic Exercise Boosts Cognitive Function, Brain Structure & Cardiovascular Health
Aerobic Exercise During Pregnancy Boosts Baby’s Brain
How Fiber and Friendly Flora Help Digestive Immunity
Anti-Aging Properties of Astaxanthin
Tocotrienols Stabilize Mast Cells
Q10, Zinc, and Antioxidants Needed During the Flu
Ubiquinol Q10 Anti-Aging Properties
Magnesium Intake Improves Insulin Resistance
Limonene Boosts Metabolism, Lowers Inflammation & Stress


Most Popular News:


Connect with Wellness Resources:

Connect on Facebook Follow us on Twitter Wellness Resources on Pinterest Wellness Resources YouTube Channel Get RSS News Feeds
Telecourse
bookstore
Thyroid and Metabolism
podcast
autoship