Ubiquinol Q10 Supplementation Activates Mitochondria Functions to Offset Aging
Results: Here, we report that dietary supplementation with ubiquinol-10 prevents age-related decreases in the expression of sirtuin gene family members that results in the activation of PGC-1α, a major factor that controls mitochondrial biogenesis and respiration, as well as SOD2 and IDH2, which are major mitochondrial antioxidant enzymes. Ubiquinol-10 supplementation can also increase mitochondrial complex I activity and decrease levels of oxidative stress markers, including protein carbonyls, AP sites, malondialdehydes, and the GSH/GSSG ratio. Furthermore, ubiquinol-10 may activate Sirt1 and PGC-1α by increasing cAMP levels that in turn activate CREB and AMPK.
Innovation and Conclusion: These results show that ubiquinol-10 may enhance mitochondrial activity by increasing levels of Sirt1, PGC-1α and Sirt3 that slow the rate of age-related hearing loss and protect against the progression of aging and symptoms of age-related diseases.
Tian G, Sawashita J, Kubo H, Nishio S, Hashimoto S, Suzuki N, Yoshimura G, Tsuruoka M, Wang Y, Liu Y, Luo H, Xu Z, Kitano M, Mori M, Hosoe K, Takeda T, Usami S, Higuchi K.
Ubiquinol-10 Supplementation Activates Mitochondria Functions to Decelerate Senescence in Senescence Accelerated Mice
Antioxid Redox Signal
Department of Aging Biology Institute of Pathogenesis and Disease Prevention Shinshu University Graduate School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Matsumoto , Japan.