Study Title:

The association of Varicella zoster virus reactivation with Bell's palsy in children.

Study Abstract


OBJECTIVES:
Bell's palsy is considered the most common cause of facial nerve paralysis in children. Although different theories have been postulated for its diagnosis, reactivation of the Varicella zoster virus (VZV) has been implicated as one of the causes of Bell's palsy. The aim of the study was to evaluate the association of Varicella-zoster virus infection with Bell's palsy and its outcome in children.

METHODS:
A total of 30 children with Bell's palsy were recruited and were assayed for evidence of VZV infection. The severity of facial nerve dysfunction and the recovery rate were evaluated according to House-Brackmann Facial Nerve Grading Scale (HB FGS). Paired whole blood samples from all patients were obtained at their initial visit and 3 weeks later, and serum samples were analyzed for VZV IgG and IgM antibodies using ELISA.

RESULTS:
A significantly higher percentage of Bell's palsy patients were seropositive for VZV IgM antibodies than controls (36.6% of patients vs 10% of controls) while for VZV IgG antibodies the difference was statistically nonsignificant. HB FGS in Bell's palsy patients with serologic evidence of VZV recent infection or reactivation showed a statistiacally significant less cure rate than other patients.

CONCLUSIONS:
VZV reactivation may be an important cause of acute peripheral facial paralysis in children. The appropriate diagnosis of VZV reactivation should be done to improve the outcome and the cure rate by the early use of antiviral treatment.

Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

KEYWORDS:
Bell's palsy; Facial paralysis; Varicella zoster virus; Zoster sine herpete

Study Information

Int J Pediatr Otorhinolaryngol. 2015 Mar;79(3):328-31. doi: 10.1016/j.ijporl.2014.12.010. Epub 2014 Dec 31.

Full Study

https://www.ncbi.nlm.nih.gov/pubmed/25599860