Effects of hyperthyroidism and hypothyroidism on glutamine metabolism by skeletal muscle of the rat
2. Hyperthyroidism decreased the concentration of glutamine in soleus muscle but was without effect on that in the gastrocnemius muscle or in the plasma. Hyperthyroidism also increased markedly the rate of release of glutamine from the incubated soleus muscle.
3. Hypothyroidism decreased the concentrations of glutamine in the gastrocnemius muscle and plasma but was without effect on that in soleus muscle. Hypothyroidism also decreased markedly the rate of glutamine release from the incubated soleus muscle.
4. Thyroid status was found to have marked effects on the rate of glutamine release by skeletal muscle per se, and may be important in the control of this process in both physiological and pathological conditions.
Biochem J. 1990 Dec 1;272(2):319-22. doi: 10.1042/bj2720319. PMID: 2268261; PMCID: PMC1149701.