New Research Shows PQQ Benefits Arthritis, Brain Inflammation and Diabetes

Linda J. Dobberstein, Chiropractor, Board Certified in Clinical Nutrition

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New Research Shows PQQ Benefits Arthritis, Brain Inflammation and Diabetes
In the last few months, the research studies on PQQ show remarkable benefits in tough chronic disorders. The results of these studies collectively suggest that PQQ is a promising therapeutic agent for alleviating the progress of chronic debilitating disorders. Individuals who want help in easing or preventing osteoarthritis, rheumatoid arthritis, diabetes, high cholesterol, and neurological stress now have a remarkable nutrient to add to their toolbox.

Osteoarthritis, Rheumatoid Arthritis and PQQ


PQQ (pyrroloquinoline quinone) is a naturally occurring redox cofactor or an extreme antioxidant. It is a powerful, magnificent essential nutrient. The recent flurry of studies linking mitochondria problems to osteoarthritis development has caused scientists to look directly at PQQ to see if it can stop the disease causing inflammatory cascade.

In an August 2015 study in the journal Inflammation, researchers described the benefits of PQQ in osteoarthritis or degenerative joint disease prevention in rodents. The joint cartilage was analyzed for the matrix metalloproteinases - MMP-1 and MMP-13 and nitric oxide (NO) and iNOS production. These inflammatory chemicals were significantly reduced and quenched with PQQ treatment. The PQQ treatment markedly decelerated the breakdown of the joint cartilage. The animals treated with the PQQ showed improved joint health and reduction in arthritis. The authors’ conclusion predicted, “owing to its beneficial effects, PQQ is expected to be a novel pharmacological application in osteoarthritis clinical prevention and treatment in the near future”.

PQQ not only is an extreme antioxidant, researchers report that it exerts potent immunosuppressive effects in cases where autoimmune inflammation is out of control. Scientists recently explored this activity with rheumatoid arthritis. Researchers studied rodents that had rheumatoid arthritis joint damage. High levels of MMP-1 and MMP-3 were found in the joints synovial fluid. Other highly inflammatory compounds, like TNF-a, IL-6, and IL-beta were also identified. These inflammatory, immune destructive compounds were significantly inhibited when PQQ was used for treatment. Preventative and support treatments with PQQ were both highly beneficial as seen under microscopic exam and clinical evaluation. The results demonstrated that PQQ alleviated the progress and joint destruction from an overactive immune system related to rheumatoid arthritis in animals. Given the vast array of dangerous side effects of anti-TNF-a immunosuppressive drugs used in rheumatoid disorders, PQQ provides a safer and highly promising natural alternative.

Brain Inflammation and PQQ


Many of the same inflammatory chemicals released in osteoarthritis and rheumatoid arthritis are also released with other disorders. This includes many neurodegenerative disorders with excessive microglial cell activity and neurological inflammation. In a recent animal study, the microglial cells or the immune system cells of the brain, were treated with the bacterial toxin LPS to induce extensive inflammation in the brain. The scientists measured several inflammatory markers such as NO, iNOS, TNF-a, NF-kappaB, IL-1 beta, IL-6, COX-2, and PGE2 in the microglial cells. PQQ inhibited the production of these neurologically inflaming chemicals released by the microglial cells. The toxic brain inflammation was quenched with PQQ. The scientists’ conclusion found that PQQ protected the delicate nerve tissues within the brain. “The results collectively suggested that PQQ might be a promising therapeutic agent for alleviating the progress of neurodegenerative diseases associated with microglial activation.”

PQQ appears to be a highly promising resource for numerous disorders linked with microglial cell inflammation. Some of the disorders linked with microglial cell inflammation include Alzheimer’s disease, Parkinson’s disease, stroke, chronic pain problems, ALS, Huntington’s disease, fibromyalgia, Chronic Fatigue Syndrome/Myalgic Encephalomyelitis, multiple sclerosis, neuropathy and immunologically induced fatigue.

Diabetes and LDL Cholesterol


In another recent study, diabetic mice were evaluated for the amount of inflammation and oxidative stress caused by diabetes and compared markers to non-diabetic mice. Researchers measured the amount of glucose, cholesterol, triglycerides, insulin, uric acid, and function of the liver, kidneys, and pancreas. High levels of oxidative stress or free radical inflammation was found in the diabetic rodents. When the animals were treated with PQQ, the blood sugar and cholesterol findings improved. The inflammatory damage to the kidneys, pancreas, and liver also improved when treated with high doses of PQQ. In this study, diabetes regression occurred with high dose PQQ after just 15 days.

LDL cholesterol levels declined when treated with BioPQQ® in a study of healthy Japanese adults. In this randomized, placebo-controlled, double-blinded study, the adults who had normal to moderately high triglycerides and elevated LDL cholesterol were treated with 20 mg of PQQ per day versus a placebo for 12 weeks. Those individuals, who received PQQ, had slight, but significant decrease in the LDL markers. The study did not evaluate the inflammatory markers or the particle size of the LDL cholesterol as this reflects how dangerous LDL may be. The fact that the LDL levels reduced with PQQ in this human study and that PQQ is known to reduce many types of inflammation, offers new support options other than toxic statin drugs.

Research continues to expand upon the benefits of PQQ in a vast array of disorders. The results are remarkable and noteworthy. The evidence that PQQ can alleviate major chronic disorders and disease progression in animal studies and human trials offers tremendous opportunity for those who may have tried “everything” and continue to struggle. PQQ may be combined with other nutrients like curcumin, boswellia, and glucosamine for broad spectrum joint and musculoskeletal support. Curcumin, resveratrol, grapeseed extract, and fisetin also support microglial cell inflammation. Colostrum may also inhibit excess microglial cell activity and inflammation and can easily be used together with PQQ for synergistic benefits. It may also be used with other cholesterol and blood sugar support like cinnamon, pantethine, DHA, and tocotrienols as needed. Give PQQ a try and see if some of those nagging problems disappear.

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