Study Title:

The Renin Angiotensin Aldosterone System in Obesity and Hypertension: Roles in the Cardiorenal Metab

Study Abstract

In the United States, more than 50 million people have blood pressure at or above 120/80 mm Hg. All components of cardiorenal metabolic syndrome (CRS) are linked to metabolic abnormalities and obesity. A major driver for CRS is obesity. Current estimates show that many of those with hypertension and CRS show some degree of systemic and cardiovascular insulin resistance. Several pathophysiologic factors participate in the link between hypertension and CRS. This article updates recent literature with a focus on the function of insulin resistance, obesity, and renin angiotensin aldosterone system-mediated oxidative stress on endothelial dysfunction and the pathogenesis of hypertension.

Copyright © 2016 Elsevier Inc. All rights reserved.
KEYWORDS:

Adipocyte; Angiotensin II; Hypertension; Insulin resistance; Obesity

Study Information


The Renin Angiotensin Aldosterone System in Obesity and Hypertension: Roles in the Cardiorenal Metabolic Syndrome.
Med Clin North Am.
2017 January

Full Study

https://www.ncbi.nlm.nih.gov/pubmed/27884224