Study Title:

Restless Legs Syndrome: clinical features, diagnosis and a practical approach to management.

Study Abstract

Restless legs syndrome (RLS) is a chronic neurological disorder that interferes with rest and sleep. It has a wide spectrum of symptom severity, and treatment is started when symptoms become bothersome. Dopamine agonists and calcium channel apha-2-delta antagonists (gabapentin, gabapentin enacarbil and pregabalin) are first-line treatments; calcium channel alpha-2-deltas are preferred over dopamine agonists because they give less augmentation, a condition with symptom onset earlier in the day and intensification of RLS symptoms. Dopamine agonists can still be used as first-line therapy, but the dose should be kept as low as possible. Iron supplements are started when the serum ferritin concentration is ≤75 µg/L, or if the transferrin saturation is less than 20%. For severe or resistant RLS, a combined treatment approach can be effective. Augmentation can be very challenging to treat and lacks evidenced-based guidelines.

augmentation; dopamine agonist; iron; periodic limb movement disorder; restless legs syndrome

PMID: 29097554 DOI: 10.1136/practneurol-2017-001762

Study Information

Pract Neurol. 2017 Dec;17(6):444-452. doi: 10.1136/practneurol-2017-001762. Epub 2017 Nov 2.

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