Lipoic Acid Improves Circulation in Subclinical Hypothyroid Patients
PATIENTS AND METHODS: Forty women with newly diagnosed sHT and 18 healthy women with euthyroid status were enrolled. Patients were randomized into 2 groups to receive no treatment (n = 20), alpha-lipoic acid (n = 20) for 3 weeks. We measured the FMD at baseline and after 3 weeks.
RESULTS: FMD in alpha-lipoic acid and no-treatment group were 3.92% and 4.02%, respectively, which were significantly lower than that in controls (5.64%) (p<0.001). After 3 weeks treatment, compared with before treatment in sHT patients, plasma thiobarbituric acid reactive substances (TBARS) levels decreased significantly in alpha-lipoic acid group (p<0.001), and remain unchanged in no-treatment group (p>0.05). FMD improved markedly (4.82%) in alpha-lipoic acid group (p<0.01), and remain unchanged in no-treatment group (p>0.05). The absolute changes in FMD showed significant negative correlation with the changes in TBARS (r = -0.773, p<0.001).
CONCLUSION: Our data showed that sHT patients exists impaired endothelial function, and antioxidant alpha-lipoic acid can improve endothelial function, through decrease of oxygen- derived free radicals.
G D X, J H P, H L S, L S Z.
Alpha-lipoic acid improves endothelial dysfunction in patients with subclinical hypothyroidism.
Department of Endocrinology, Wuhan General Hospital of Guangzhou Command, Hubei Province, PR China