Grape Seed Extract as a Potential Remineralizing Agent
Materials and methods: Sound human tooth sections were obtained from the cervical portion of the root and stored in demineralizing solution at 37°C for 96 hours to induce artificial root caries lesions. The sections were divided into four treatment groups including 6.5% grape seed extract, sodium monofluorophosphate (220 ppm) with 0.05% calcium glycerophosphate, 0.5% calcium glycerophosphate and control (no treatment). An in vitro pH cycling model was used to cycle the demineralized specimens through treatment solutions, acidic buffer and neutral buffer for 8 days at 6 cycles per day. Subsequently, they were evaluated using confocal laser scanning microscope. Data were analyzed using analysis of variance (p < 0.05).
Results: GSE revealed less demineralization and more remineralization compared with other groups.
Conclusion: GSE promotes remineralization of artificial root caries lesions. Clinical significance: The search for the perfect remineralizing agent continues to this day. GSE could be a welcome addition to the remineralization armamentarium.
Benjamin S, Sharma R, Thomas SS, Nainan MT.
Grape Seed Extract as a Potential Remineralizing Agent: A Comparative in vitro Study.
J Contemp Dent Pract
Department of Conservative Dentistry and Endodontics, Vydehi Institute of Dental Sciences, Bengaluru, Karnataka, India.