Study Title:

GABAergic neurons in cerebellar interposed nucleus modulate cellular and humoral immunity via hypoth

Study Abstract

Our previous work has shown that cerebellar interposed nucleus (IN) modulates immune function. Herein, we reveal mechanism underlying the immunomodulation. Treatment of bilateral cerebellar IN of rats with 3-mercaptopropionic acid (3-MP), a glutamic acid decarboxylase antagonist that reduces γ-aminobutyric acid (GABA) synthesis, enhanced cellular and humoral immune responses to bovine serum albumin, whereas injection of vigabatrin, a GABA-transaminase inhibitor that inhibits GABA degradation, in bilateral cerebellar IN attenuated the immune responses. The 3-MP or vigabatrin administrations in the cerebellar IN decreased or increased hypothalamic GABA content and lymphoid tissues' norepinephrine content, respectively, but did not alter adrenocortical or thyroid hormone levels in serum. In addition, a direct GABAergic projection from cerebellar IN to hypothalamus was found. These findings suggest that GABAergic neurons in cerebellar IN regulate immune system via hypothalamic and sympathetic pathways.
Copyright © 2015 Elsevier B.V. All rights reserved.
KEYWORDS:
Cellular immunity; Cerebellar interposed nucleus; Cerebellar-hypothalamic projection; GABA; Humoral immunity

Study Information


GABAergic neurons in cerebellar interposed nucleus modulate cellular and humoral immunity via hypothalamic and sympathetic pathways
J Neuroimmunol.
2015 June

Full Study

http://www.ncbi.nlm.nih.gov/pubmed/26004153