Study Title:

Elevated serum leptin levels are associated with low vitamin D, sarcopenic obesity, poor muscle strength, and physical performance in knee osteoarthritis.

Study Abstract

CONTEXT:
The associations between serum leptin, vitamin D status, sarcopenic obesity, muscle strength and physical performance in osteoarthritis (OA) remain uncertain.

OBJECTIVE:
To analyse the relationships between serum leptin, vitamin D status, muscle strength and physical performance in OA patients.

METHODS:
A total of 208 knee OA patients were enrolled. Serum leptin, vitamin D, muscle strength and physical performance were evaluated.

RESULTS:
OA patients with sarcopenic obesity had significantly higher serum leptin levels than those with non-sarcopenic obesity. In addition, knee OA patients with sarcopenic obesity displayed low grip strength and poor physical performance. Furthermore, high serum leptin was negatively associated with vitamin D and physical performance.

CONCLUSIONS:
Serum leptin levels were correlated with low vitamin D, reduced muscle strength and functional impairment, suggesting that serum leptin might serve as a biomarker reflecting physical performance in OA patients.

KEYWORDS:
Leptin; muscle strength; osteoarthritis; physical performance; sarcopenic obesity; vitamin D

Study Information

Biomarkers. 2017 Dec;22(8):723-730. doi: 10.1080/1354750X.2017.1315615. Epub 2017 Apr 19.

Full Study

https://www.ncbi.nlm.nih.gov/pubmed/28374624