Study Title:

Effects of quercetin on LPS-induced disseminated intravascular coagulation (DIC) in rabbits.

Study Abstract

INTRODUCTION:
Quercetin is widely distributed in plants and has been reported to have effects of anti-inflammation and anti-thrombosis. In this study, we evaluated the protective effect of quercetin on LPS-induced experimental DIC in rabbits, and tried to clarify its mechanism against DIC.

MATERIALS AND METHODS:
LPS-induced DIC model in rabbits was established through continuous infusion of 100 ug•kg(-1)•h(-1) LPS for a period of 6h. Six groups were divided: quercetin-treated groups (0.5, 1.0, and 2.0mg•kg(-1)•h(-1), respectively), LPS-control group, heparin-control group (100IU•kg(-1)•h(-1)), and saline-control group. APTT, PT, and plasma FIB level were measured, the plasma levels of ALT, BUN, and TNF-α were detected, and the activity of Protein C and ATIII was recorded.

RESULTS:
A continuous injection of LPS induced a gradual impairment of hemostatic parameters, a rise in plasma level of TNF-α, and damage in renal and hepatic function. The intravenous administration of quercetin significantly attenuated the increase of APTT, PT, ALT, BUN, and TNF-α, and the decrease of plasma FIB level and activity of Protein C and ATIII.

CONCLUSION:
Quercetin may have a protective effect against LPS-induced DIC in rabbits through anti-inflammation and anticoagulation.

Study Information

Yu PX, Zhou QJ, Zhu WW, Wu YH, Wu LC, Lin X, Chen MH, Qiu BT.
Effects of quercetin on LPS-induced disseminated intravascular coagulation (DIC) in rabbits.
Thromb Res.
2013 June
Department of Pharmacology, Medical College, Ji-nan University, Guangzhou, China.

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