Study Title:

Curcumin could prevent the development of chronic neuropathic pain in rats with peripheral nerve inj

Study Abstract

BACKGROUND:

Peripheral nerve injury results in chronic neuropathic pain characterized by allodynia and/or spontaneous pain. It has been suggested that activation of mitogen-activated protein kinases such as extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) contribute to the neuropathic pain.
OBJECTIVES:

We investigated if curcumin could prevent the development of neuropathic pain in rats with chronic constriction injury (CCI) of the sciatic nerve.
METHODS:

The animals were divided into 3 groups. In the curcumin treatment group (n = 10), curcumin (50 mg/kg/d PO) was administered once daily from 1 day before CCI to 7 days after CCI. The rats in the sham group (n = 10) and CCI group (n = 10) received a control vehicle. The mechanical allodynia was assessed using von Frey at 1, 3, 5, and 7 days after nerve injury. Western blots were used to evaluate the levels of p-ERK, p-JNK, and phosphorylation of NR1 (p-NR1) subunits of N-methyl-D-aspartate in the spinal dorsal root ganglion.
RESULTS:

In the CCI group, mechanical allodynia was observed during 7 days after nerve injury. However, curcumin treatment reversed the mechanical allodynia 7 days after nerve ligation. There were no differences in the expression of p-ERK, p-JNK, and p-NR1 between the sham and curcumin groups. However, the expression of p-ERK, p-JNK, and p-NR1 in the CCI group were higher than the sham group and curcumin group, respectively (P < 0.05).
CONCLUSIONS:

Treatment with curcumin during the early stages of peripheral neuropathy can prevent the development of chronic neuropathic pain.
KEYWORDS:

curcumin; mitogen-activated protein kinases; neuropathic pain

Study Information


Curcumin could prevent the development of chronic neuropathic pain in rats with peripheral nerve injury.
Curr Ther Res Clin Exp.
2013 June

Full Study

http://www.ncbi.nlm.nih.gov/pubmed/24385078