Study Title:

Cardiovascular disease in patients with coeliac disease: A systematic review and meta-analysis

Study Abstract

BACKGROUND:
Coeliac disease has been associated with an increased risk of cardiovascular disease in some studies, whereas other studies have shown no association. We performed a systematic review and meta-analysis of cardiovascular disease in celiac disease.
METHODS:
Pubmed, Cinahl, EMBASE and Medline via Ovid were searched for relevant articles published until January 5, 2015. English-language articles on studies with more than 20 patients were included, and were quality rated using the GRADE risk of bias tool. We used random-effects models and assessed heterogeneity using the I(2) statistic.
RESULTS:
Ten studies were relevant, reporting the risk of myocardial infarction, cardiovascular death and stroke in 33,128/32,903/32,466 coeliac disease patients respectively. Only one study examined celiac disease and a composite measure of cardiovascular disease and this study found a hazard ratio of 1.10 (95%CI 1.03-1.28). In a meta-analysis, we observed an increased risk of stroke (OR 1.11; 95%CI 1.02-1.20). The risks of myocardial infarction (OR 1.12; 95%CI 0.83-1.40) and cardiovascular death (OR 1.12; 95%CI 0.96-1.29) were similar but were estimated with less certainty. Heterogeneity was low for all outcomes except for myocardial infarction where it was moderate.
CONCLUSION:
Coeliac disease was associated with a modestly increased risk of cardiovascular disease, but the evidence base is limited.
Copyright © 2015 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
KEYWORDS:
Cardiovascular disease; Celiac; Coeliac; Meta-analysis

Study Information


Cardiovascular disease in patients with coeliac disease: A systematic review and meta-analysis
Dig Liver Dis.
2015 October

Full Study

http://www.ncbi.nlm.nih.gov/pubmed/26160499