Resveratrol Protects Blood-Brain Barrier

Byron J. Richards, Board Certified Clinical Nutritionist

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Resveratrol Protects Blood-Brain Barrier
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Entry of substances into your brain is closely regulated by your blood-brain barrier, preventing toxins and other damaging molecules from entering your brain and wreaking havoc. A new animal study shows that resveratrol protects the blood-brain barrier1 from damage otherwise caused by oxidized LDL cholesterol.

The integrity of the cells that make up your blood brain barrier is similar to the offensive line of a football team protecting their quarterback. When the linemen are tightly lined up then the quarterback is protected. This concept is especially important when the offensive line is under a blitz or other heavy pressure. Oxidized LDL cholesterol is a highly reactive compound capable of inflicting serious damage to the blood-brain barrier – a common problem for people with cholesterol, blood pressure, stress, and/or circulatory problems. Under such stress the blood-brain barrier becomes “leaky” or permeable, allowing toxic compounds into the brain with subsequent wear and tear to nerves.

In this study resveratrol prevented damage to the blood-brain barrier when exposed to oxidized LDL cholesterol. The tight junctions between linemen were maintained. In fact, resveratrol prevented the lineman from getting fatigue – enabling them to keep blocking effectively for a prolonged period of time.

Resveratrol is a nutrient worth having on your team.

Referenced Studies

  1. ^ Resveratrol Protects against Oxidized LDL-Induced Breakage of the Blood-Brain Barrier  Journal of Nutrition  Yi‑Ling Lin, Huai‑Chia Chang, Ta‑Liang Chen, Jin‑Han Chang, Wen‑Ta Chiu, Jia‑Wei Lin, and Ruei‑Ming Chen.

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