Another Resveratrol Anti-Aging Breakthrough

Byron J. Richards, Board Certified Clinical Nutritionist

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Another Resveratrol Anti-Aging Breakthrough
A new mechanism has been identified that explains one novel way that resveratrol not only helps prevent aging but may help reverse it. It involves a unique way in which the resveratrol-activated SIRT1 guards your DNA1. In the new study the researchers state: “We see here, through a proof-of-principal demonstration, that elements of aging can be reversed.”

The researchers expanded on their earlier work with yeast and found that a novel mechanism also applies to mammals. One of SIRT1's duties is to stand guard over gene switches to ensure only those that are relevant to healthy function of that type of cell are activated. When a cell is stressed by toxins, free radicals, germs, UV radiation, inflammation, or something else it can cause DNA damage. Under these circumstances SIRT1 leaves its guard post and helps out with emergency DNA repair. While SIRT1 is gone from guard duty genes can activate that should not, causing cell dysregulation and aging. In a healthy situation, once SIRT1 finishes DNA repair then it returns to guard duty and re-establishes proper gene regulation that may have gone awry while it was gone.

The researchers proved that one common theme of aging is that SIRT1 is not on guard duty adequately. Aging is invariably accompanied by too many wrong gene signals activated too often. The greater the DNA damage the faster the aging, due in no small part to the improper gene activation (not necessarily the DNA damage itself).

The researchers also found that giving resveratrol to mice that lacked adequate SIRT1 for proper guard duty restored their gene signals to healthy and reversed aging. This is a major breakthrough in anti-aging science.

Referenced Studies

  1. ^ A New Way Resveratrol Regulates Aging  Cell  Philipp Oberdoerffer et al.

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