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system* Improves leg circulation and vein health* Improves oxygen utilization during exercise* Enhances weight management efforts* Features resveratrol and grape seed extract polyphenols 25% off in February!Cardio Helper™ is our premier nutritional supplement to support circulation, str...
90 capsules $42.00 $31.50
c acid, milk thistleDaily Balancer™ is our top nutritional formula for the liver. It supports the natural processes of detoxification.* Features resveratrol, chlorella, milk thistle extract, l-carnosine and r-alpha lipoic acid. Daily Balancer - Detoxification supplement with res...
that support healthy estrogen metabolism and clearance of toxins.* Includes cruciferous vegetable concentrates for a healthy body. Now contains more resveratrol and green tea extract! Preventer Plus - Nutritional Supplement with I3C, DIM, resveratrol, Green Tea Extract, Querc...
60 capsules $30.00 $24.00
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Showing 3 of 257 View all news results >
There are a lot of great anti-aging and metabolism boosting nutrients: DHA, pantethine, acetyl-l-carnitine, carnosine, r-alpha lipoic acid, grape ...
... lot of great anti-aging and metabolism boosting nutrients: DHA, pantethine1, acetyl-l-carnitine, carnosine, r-alpha lipoic acid, grape seed extracts – the list goes on and on. In fact, most nutrients help cells function better and thus live longer. So, why is resveratrol vying for the position as King of the anti-aging nutrients – with a potent fat-burning twist thrown in for good measure? Maybe we should ask Big Pharma, who is spending a pile of cash on metabolites of resveratrol3 that they hope to patent as weight loss drugs ...
Resveratrol, Found In Red Wine, Wards Off Effects Of Age On Heart, Bones, Eyes And Muscle.
... Study Title: Resveratrol Improves Bone Health, Reduces Cataracts,& Improves Coordination Study Abstract From press release:Scientists have found that the compound resveratrol-- found in red wine and grape skin-- slows age-related deterioration and functional decline of mice on a standard diet, but does not increase longevity when started at middle age.This study, conducted and supported in part by the National Institute on Aging (NIA), part of the National Institutes of Health, is a follow-up to 2006 findings that resveratrol improves health and longevity of ...
The aging process is marked by increasing levels of free radical damage and inflammation. These processes injure multiple body tissues including t...
... The aging process is marked by increasing levels of free radical damage and inflammation. These processes injure multiple body tissues including those that comprise the circulatory system. In turn, circulation becomes "leaky" and inefficient, setting the stage for significant health problems. Several recent resveratrol studies identify how resveratrol provides near miraculous benefits to circulatory health, working to directly counter the forces of aging. Neurovascular coupling is the process by which neurons and glial cells work in harmony with endothelial cells of the circulatory system to enable smooth blood flow in the ...

Health Topics

Resveratrol is an important nutrient which helps the body form SIRT1 which is helpful for Weight Management and Leptin Resistance problems.
... Resveratrol Activates SIRT1 for Weight Management Resveratrol is a nutrient known to activate a potent gene signal called SIRT1. SIRT1 first drew attention as the primary gene signal involved with the longevity benefits of calorie restriction. A very simple explanation is that when you are in a food scarcity situation, SIRT1 is activated to help break down your stored fat to use as fuel as well as boost your energy so that you have enough energy to hunt for new food. SIRT1 is part of a famine related survival system. It is important to ...
Resveratrol is an important nutrient which helps the body form SIRT1 which is helpful for Weight Management and Leptin Resistance problems.
... Resveratrol Activates SIRT1 for Weight Management Resveratrol is a nutrient known to activate a potent gene signal called SIRT1. SIRT1 first drew attention as the primary gene signal involved with the longevity benefits of calorie restriction. A very simple explanation is that when you are in a food scarcity situation, SIRT1 is activated to help break down your stored fat to use as fuel as well as boost your energy so that you have enough energy to hunt for new food. SIRT1 is part of a famine related survival system. It is important to ...
Resveratrol, grape seed extract, and hawthorne, and horse chestnut are nutrients that support heart health and integrity of the arteries, veins, a...
... are tighter or there are sock lines on your legs. Such mild fluid retention can often be corrected with nutrients that help to reduce stress in the circulation and "seal up" the leaky capillaries, thus supporting healthy blood pressure fitness.* Cardio Helper™ contains resveratrol, grape seed extract, hawthorn berry and horse chestnut, four powerful nutrients that nourish the lining of the arteries and capillaries so that their integrity is enhanced. This helps keep water correctly within the circulation and thus helps maintain correct blood pressure.* ADD TO ...

Study

Resveratrol, Found In Red Wine, Wards Off Effects Of Age On Heart, Bones, Eyes And Muscle.
... Study Title: Resveratrol Improves Bone Health, Reduces Cataracts,& Improves Coordination Study Abstract From press release:Scientists have found that the compound resveratrol-- found in red wine and grape skin-- slows age-related deterioration and functional decline of mice on a standard diet, but does not increase longevity when started at middle age.This study, conducted and supported in part by the National Institute on Aging (NIA), part of the National Institutes of Health, is a follow-up to 2006 findings that resveratrol improves health and longevity of ...
The Biological Responses to Resveratrol and Other Polyphenols From Alcoholic Beverages.
... Study Title: Resveratrol Health Benefits Update Study Abstract Although excessive consumption of ethanol in alcoholic beverages causes multi-organ damage, moderate consumption, particularly of red wine, is protective against all-cause mortality. These protective effects could be due to one or many components of the complex mixture of bioactive compounds present in red wine including flavonols, monomeric and polymeric flavan-3-ols, highly colored anthocyanins as well as phenolic acids and the stilbene polyphenol, resveratrol. The therapeutic potential of resveratrol, firstly in cancer chemoprevention and then later for cardioprotection, has stimulated many ...
Resveratrol Regulates Pathologic Angiogenesis by a Eukaryotic Elongation Factor-2 Kinase-Regulated Pathway
... Study Title: Resveratrol and Eye Health Study Abstract Abnormal angiogenesis is central to the pathophysiology of diverse disease processes including cancers, ischemic and atherosclerotic heart disease, and visually debilitating eye disease. Resveratrol is a naturally occurring phytoalexin that has been demonstrated to ameliorate and decelerate the aging process as well as blunt end organ damage from obesity. These effects of resveratrol are largely mediated by members of the sirtuin family of proteins. We demonstrate that resveratrol can inhibit pathological angiogenesis in vivo and in vitro by a sirtuin-independent pathway. Resveratrol inhibits the ...

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Showing 5 of 5
system* Improves leg circulation and vein health* Improves oxygen utilization during exercise* Enhances weight management efforts* Features resveratrol and grape seed extract polyphenols 25% off in February!Cardio Helper™ is our premier nutritional supplement to support circulation, str...
90 capsules $42.00 $31.50
c acid, milk thistleDaily Balancer™ is our top nutritional formula for the liver. It supports the natural processes of detoxification.* Features resveratrol, chlorella, milk thistle extract, l-carnosine and r-alpha lipoic acid. Daily Balancer - Detoxification supplement with res...
that support healthy estrogen metabolism and clearance of toxins.* Includes cruciferous vegetable concentrates for a healthy body. Now contains more resveratrol and green tea extract! Preventer Plus - Nutritional Supplement with I3C, DIM, resveratrol, Green Tea Extract, Querc...
60 capsules $30.00 $24.00
163025. Top supplements for cholesterol metabolism, blood pressure, and circulation* Convenient, on-the-go packets Comprehensive combination of nutrients for cardiovascular health* 30% off in February!The LeptiCardio Pack™ contains top cardiovascular health...
60 packets $183.00 $128.10
3520. Enhances repair of body tissues* Improves joint and skin health* Supports healthy immune response* Improves internal cleansing* Supports cardiovascular health* Contains curcumin, quercetin, bromelain, papain, black pepper extract*Repair Plus™ contains...
100 capsules $37.00 $29.60

News

Showing 10 of 257 View all news results >
There are a lot of great anti-aging and metabolism boosting nutrients: DHA, pantethine, acetyl-l-carnitine, carnosine, r-alpha lipoic acid, grape ...
... lot of great anti-aging and metabolism boosting nutrients: DHA, pantethine1, acetyl-l-carnitine, carnosine, r-alpha lipoic acid, grape seed extracts – the list goes on and on. In fact, most nutrients help cells function better and thus live longer. So, why is resveratrol vying for the position as King of the anti-aging nutrients – with a potent fat-burning twist thrown in for good measure? Maybe we should ask Big Pharma, who is spending a pile of cash on metabolites of resveratrol3 that they hope to patent as weight loss drugs ...
Resveratrol, Found In Red Wine, Wards Off Effects Of Age On Heart, Bones, Eyes And Muscle.
... Study Title: Resveratrol Improves Bone Health, Reduces Cataracts,& Improves Coordination Study Abstract From press release:Scientists have found that the compound resveratrol-- found in red wine and grape skin-- slows age-related deterioration and functional decline of mice on a standard diet, but does not increase longevity when started at middle age.This study, conducted and supported in part by the National Institute on Aging (NIA), part of the National Institutes of Health, is a follow-up to 2006 findings that resveratrol improves health and longevity of ...
The aging process is marked by increasing levels of free radical damage and inflammation. These processes injure multiple body tissues including t...
... The aging process is marked by increasing levels of free radical damage and inflammation. These processes injure multiple body tissues including those that comprise the circulatory system. In turn, circulation becomes "leaky" and inefficient, setting the stage for significant health problems. Several recent resveratrol studies identify how resveratrol provides near miraculous benefits to circulatory health, working to directly counter the forces of aging. Neurovascular coupling is the process by which neurons and glial cells work in harmony with endothelial cells of the circulatory system to enable smooth blood flow in the ...
Resveratrol is one of nature's anti-aging tools. It also boosts health and stops free radical damage, unlike man-made drugs that strive to co...
... health while hopefully not causing too much damage, nature provides potent remedies that simultaneously influence multiple aspects of health while being free of adverse side effects. There simply is no comparison. The more science looks into the mechanisms of natural remedies the more impressive they become. Resveratrol is a case in point. Resveratrol is best known for its activation of the SIRT1 gene that is associated with longevity. SIRT1 is also activated by dietary restriction, and shut down when a person eats too much, which is why many people are speeding their ...
Reseveratrol is one of nature’s multi-taskers; boosting male reproductive health is one of its strengths.
... update your Flash plugin. This Week's Health Podcast In my article last month, Natural Supplements for Male Sexual Performance, I explained the vital importance of a good supply of friendly nitric oxide (eNOS) for both male health and cardiovascular health. The emerging science on resveratrol now indicates its help in support of male sexual function. It has been known for a while that resveratrol helps boost the production of eNOS by turning on the enzyme that helps make it (nitric oxide synthase). This alone would tend to be beneficial for ...
The scientific evaluation of resveratrol continues to impress one and all, with recent research showing extreme protection against the chain of ev...
... | Byron J. Richards, Board Certified Clinical Nutritionist Listen to Byron Explain play pause mute unmute Update Required To play the media you will need to either update your browser to a recent version or update your Flash plugin. This Week's Health Podcast The scientific evaluation of resveratrol continues to impress one and all, with recent research showing extreme protection against the chain of events that leads to cognitive decline and the risk for dementia and Alzheimer's. Many nutrients now show impressive ability to support the health of your brain and resveratrol sits right at ...
Falling is a major concern for seniors as they age; many seniors who fall experience hip fracture, and die the following year. A new study shows t...
... This Week's Health Podcast Falling is a major issue for seniors as they age. One-third of adults over 65 fall every year, and one-quarter of adults who experience a hip fracture die the following year. A new animal study suggests help for seniors. It demonstrates that resveratrol can help return better balance and coordination, partly by protecting nerves from deterioration. "Our study suggests that a natural compound like resveratrol, which can be obtained either through dietary supplementation or diet itself, could actually decrease some of the motor deficiencies that are seen ...
Red Wine's Resveratrol May Help Battle Obesity.
... Study Title: Resveratrol Assists Weight Loss In A Variety of Ways Study Abstract From press release:Resveratrol, a compound present in grapes and red wine, reduces the number of fat cells and may one day be used to treat or prevent obesity, according to a new study.Past research found that resveratrol protected laboratory mice that were fed a high-calorie diet from the health problems of obesity, by mimicking the effects of calorie restriction. Researchers at the University of Ulm in Germany wanted to know if resveratrol could mimic the effects of calorie ...
Our bodies are meant to be used. Once in motion, multiple genes are turned on that facilitate health. These genes simply don’t turn on w...
... plugin. This Week's Health Podcast Our bodies are meant to be used. Once in motion, multiple genes are turned on that facilitate health. These genes simply don't turn on when you sit in a chair all day or lay on a couch all night. Maybe resveratrol can help. According to Gerald Weissmann, M.D., Editor-in-Chief of the FASEB Journal, "There's overwhelming data showing that the human body needs physical activity, but for some of us, getting that activity isn't easy. A low gravity environment makes it nearly ...
Resveratrol could complement the gold standard therapy in helping prevent cardiovascular disease.
... Byron J. Richards, Board Certified Clinical Nutritionist Listen to Byron Explain play pause mute unmute Update Required To play the media you will need to either update your browser to a recent version or update your Flash plugin. This Week's Health Podcast A one year study of resveratrol supplementation in patients at high risk for cardiovascular disease found that resveratrol lowered multiple markers of inflammation (including CRP by 26 percent), as well as reduced clotting factors associated with stroke. It boosted adiponectin, which improves insulin function and reduces insulin resistance. Researchers ...

Health Topics

Resveratrol is an important nutrient which helps the body form SIRT1 which is helpful for Weight Management and Leptin Resistance problems.
... Resveratrol Activates SIRT1 for Weight Management Resveratrol is a nutrient known to activate a potent gene signal called SIRT1. SIRT1 first drew attention as the primary gene signal involved with the longevity benefits of calorie restriction. A very simple explanation is that when you are in a food scarcity situation, SIRT1 is activated to help break down your stored fat to use as fuel as well as boost your energy so that you have enough energy to hunt for new food. SIRT1 is part of a famine related survival system. It is important to ...
Resveratrol is an important nutrient which helps the body form SIRT1 which is helpful for Weight Management and Leptin Resistance problems.
... Resveratrol Activates SIRT1 for Weight Management Resveratrol is a nutrient known to activate a potent gene signal called SIRT1. SIRT1 first drew attention as the primary gene signal involved with the longevity benefits of calorie restriction. A very simple explanation is that when you are in a food scarcity situation, SIRT1 is activated to help break down your stored fat to use as fuel as well as boost your energy so that you have enough energy to hunt for new food. SIRT1 is part of a famine related survival system. It is important to ...
Resveratrol, grape seed extract, and hawthorne, and horse chestnut are nutrients that support heart health and integrity of the arteries, veins, a...
... are tighter or there are sock lines on your legs. Such mild fluid retention can often be corrected with nutrients that help to reduce stress in the circulation and "seal up" the leaky capillaries, thus supporting healthy blood pressure fitness.* Cardio Helper™ contains resveratrol, grape seed extract, hawthorn berry and horse chestnut, four powerful nutrients that nourish the lining of the arteries and capillaries so that their integrity is enhanced. This helps keep water correctly within the circulation and thus helps maintain correct blood pressure.* ADD TO ...
New science shows bones regulate blood sugar. Improve metabolism, blood sugar, bone density, and weight gain. Osteoblast and osteoclast function i...
... , are already known to benefit bones directly. Nutrients that help boost adiponectin are synergistic with the role of osteocalcin stimulating adiponectin. Nutrients known to support adiponectin production include vitamin D, DHA, magnesium, zinc, quercetin, curcumin, colostrum, grape seed extract, resveratrol, and mangosteen.* Interestingly, many of these same nutrients have also been shown to support healthy osteoblast and osteoblast balance, lending to the theory that they may boost adiponectin production by assisting osteocalcin production (something that hasn't been demonstrated yet because nobody has thought ...
Adiponectin, like leptin, is a hormone made in your white adipose tissue. Adiponectin supports healthy blood sugar metabolism.
... , the greater the depression of adiponectin. This means that to fully solve an adiponectin problem you must lose any extra weight you have. As you are doing that, various nutrients have been shown to support healthy adiponectin production. These include the fish oil DHA, resveratrol, and grape seed extract.* Comprehensive support for weight management, such as the Leptin Control Pack, is quite helpful to stay in a good weight management pattern along with diet and exercise.* Sale ADD TO CART Leptin Control Pack® In Stock Estimated ...
Wellness Resources provides safe and effective nutritional supplements for improving circulation.
... the fitness of the heart itself-- helping your heart use oxygen more efficiently and therefore, helping you exercise more efficiently.* Learn more: Blood Pressure| Cholesterol ADD TO CART Cardio Helper™ Reduced price! In Stock Provides the finest quality extracts of trans resveratrol, grape seed extract, hawthorn berry, and horse chestnut. It is designed to support and enhance circulatory integrity and nourish your heart. By enhancing circulation, oxygen is more readily transported and made available to cells and muscles. This supports healthy blood pressure and ...
Wellness Resources provides safe and effective nutritional supplements. The best nutritional supplements for blood pressure, circulation, and opti...
... $12.00 20% off! 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 ADD TO CART ADD TO CART Cardio Helper™ Reduced price! In Stock Cardio Helper™ includes the finest quality extracts of trans resveratrol, grape seed extracts, hawthorn, and horsechestnut. It is designed to support and enhance circulatory integrity and nourish your heart. By enhancing circulation, oxygen is more readily transported and made available to cells. This supports healthy blood pressure and effective delivery of nutrition ...
Wellness Resources cellulite supplements can greatly help reduce visible cellulite.
... .* 25% off! 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 ADD TO CART ADD TO CART Cardio Helper™ Reduced price! In Stock Cardio Helper™ includes the finest quality extracts of trans resveratrol, grape seed extracts, hawthorn, and horsechestnut. It is designed to support and enhance circulatory integrity and nourish your heart. By enhancing circulation, oxygen is more readily transported and made available to cells. This supports healthy blood pressure and effective delivery of nutrition ...
Wellness Resources high quality weigh protein provides excellent structural support for your body.
... for athletes or active individuals. Wellness Resources formulates superior quality nutritional supplements for natural body repair, building muscle strength, and enhancing physical performance. Also see: Sports Nutrition ADD TO CART Cardio Helper™ Reduced price! In Stock Cardio Helper provides a high amount of resveratrol (the healthy component of red wine) and red grape seed extract for rejuvenating skin and veins. It also includes hawthorn extract and horse chestnut for circulation and heart health. This outstanding nutrient combination improves oxygen utilization in the body and reduces fluid retention in the ...
Wellness Resources provides safe and effective nutritional supplements. The best nutritional supplements for blood pressure, circulation, and opti...
... $12.00 20% off! 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 ADD TO CART ADD TO CART Cardio Helper™ Reduced price! In Stock Cardio Helper™ includes the finest quality extracts of trans resveratrol, grape seed extracts, hawthorn, and horsechestnut. It is designed to support and enhance circulatory integrity and nourish your heart. By enhancing circulation, oxygen is more readily transported and made available to cells. This supports healthy blood pressure and effective delivery of nutrition ...
Resveratrol, Found In Red Wine, Wards Off Effects Of Age On Heart, Bones, Eyes And Muscle.
... Study Title: Resveratrol Improves Bone Health, Reduces Cataracts,& Improves Coordination Study Abstract From press release:Scientists have found that the compound resveratrol-- found in red wine and grape skin-- slows age-related deterioration and functional decline of mice on a standard diet, but does not increase longevity when started at middle age.This study, conducted and supported in part by the National Institute on Aging (NIA), part of the National Institutes of Health, is a follow-up to 2006 findings that resveratrol improves health and longevity of ...
The Biological Responses to Resveratrol and Other Polyphenols From Alcoholic Beverages.
... Study Title: Resveratrol Health Benefits Update Study Abstract Although excessive consumption of ethanol in alcoholic beverages causes multi-organ damage, moderate consumption, particularly of red wine, is protective against all-cause mortality. These protective effects could be due to one or many components of the complex mixture of bioactive compounds present in red wine including flavonols, monomeric and polymeric flavan-3-ols, highly colored anthocyanins as well as phenolic acids and the stilbene polyphenol, resveratrol. The therapeutic potential of resveratrol, firstly in cancer chemoprevention and then later for cardioprotection, has stimulated many ...
Resveratrol Regulates Pathologic Angiogenesis by a Eukaryotic Elongation Factor-2 Kinase-Regulated Pathway
... Study Title: Resveratrol and Eye Health Study Abstract Abnormal angiogenesis is central to the pathophysiology of diverse disease processes including cancers, ischemic and atherosclerotic heart disease, and visually debilitating eye disease. Resveratrol is a naturally occurring phytoalexin that has been demonstrated to ameliorate and decelerate the aging process as well as blunt end organ damage from obesity. These effects of resveratrol are largely mediated by members of the sirtuin family of proteins. We demonstrate that resveratrol can inhibit pathological angiogenesis in vivo and in vitro by a sirtuin-independent pathway. Resveratrol inhibits the ...
Resveratrol protects against experimental stroke: Putative neuroprotective role of heme oxygenase 1
... Study Title: Resveratrol Reduces Stroke Damage Study Abstract Epidemiological and experimental reports have linked mild-to-moderate wine and/or grape consumption to a lowered incidence of cardiovascular, cerebrovascular, and peripheral vascular risk. This study revealed that resveratrol, an enriched bioactive polyphenol in red wine, selectively induces heme oxygenase 1 (HO1) in a dose- and time-dependent manner in cultured mouse cortical neuronal cells and provides neuroprotection from free-radical or excitotoxicity damage. This protection was lost when cells were treated with a protein synthesis or heme oxygenase inhibitor, suggesting that ...
An Antiinflammatory and Reactive Oxygen Species Suppressive Effects of an Extract of Polygonum Cuspidatum Containing Resveratrol
... Study Title: Resveratrol Lowers Inflammation and Free Radical Production in Humans Study Abstract Background: Resveratrol have been shown to exert an antiinflammatory and antiaging effects in vitro and in animal models.Objective: The objective of the study was to investigate the effect of a Polygonum cuspidatum extract (PCE) containing resveratrol on oxidative and inflammatory stress in normal subjects.Research Design and Methods: Two groups (10 each) of normal-weight healthy subjects were randomized to placebo or PCE containing 40 mg resveratrol daily for 6 wk. Fasting blood samples were obtained prior to and ...
... Study Title: Resveratrol prevents alveolar bone loss in an experimental rat model of periodontitis.Study Abstract Resveratrol is an antioxidant and anti-inflammatory polyphenol. Periodontitis is induced by oral pathogens, where a systemic inflammatory response accompanied by oxidative stress is the major event initiating disease. We investigated how resveratrol modulates cellular responses and the mechanisms related to this modulation in lipopolysaccharide (LPS) -stimulated human gingival fibroblasts (hGFs). We also explored whether resveratrol protects rats against alveolar bone loss in an experimental periodontitis model. Periodontitis was induced around the ...
Unique vascular protective properties of natural products: supplements or future main-line drugs with significant anti-atherosclerotic potential?
... Study Title: Resveratrol as a Main-Line Therapy for Cardio Health Study Abstract Natural health products (NHP) which include minerals, vitamins and herbal remedies are not generally considered by medical practitioners as conventional medicines and as such are not frequently prescribed by health centre's as either main-line or supplemental treatments. In the field of cardiovascular medicine, studies have shown that typically, less than half of patients suffering from coronary syndromes chose to take any form of NHP supplement and these products are rarely recommended by their medical practitioner. Vascular/endothelial cell ...
Red Wine's Resveratrol May Help Battle Obesity.
... Study Title: Resveratrol Assists Weight Loss In A Variety of Ways Study Abstract From press release:Resveratrol, a compound present in grapes and red wine, reduces the number of fat cells and may one day be used to treat or prevent obesity, according to a new study.Past research found that resveratrol protected laboratory mice that were fed a high-calorie diet from the health problems of obesity, by mimicking the effects of calorie restriction. Researchers at the University of Ulm in Germany wanted to know if resveratrol could mimic the effects of calorie ...
Vardenafil and resveratrol synergistically enhance the nitric oxide/cyclic guanosine monophosphate pathway in corpus cavernosal smooth muscle cell...
... Study Title: Resveratrol and Erectile Dysfunction Study Abstract INTRODUCTION:Phosphodiesterase type 5 (PDE5) inhibitors are very effective agents for erectile dysfunction; however, specific patient populations are hard to treat. The efficacy of PDE5 inhibitors is limited because a minimum amount of nitric oxide (NO) is necessary. Resveratrol, a plant polyphenol, is reported to activate endothelial NO synthase (eNOS) through activation of sirtuin 1. We previously reported that human corpus cavernosal smooth muscle cells (CCSMCs) express eNOS and synthesize cyclic guanosine monophosphate ( ...
Profound negative regulatory effects by resveratrol on vascular smooth muscle cells: a role of p53-p21(WAF1/CIP1) pathway.
... Study Title: Resveratrol Selectively Inhibits Only Abnormal Cell Growth in Artery Walls Study Abstract We investigated the role of resveratrol, a polyphenol rich in red wine, in cell cycle progression and apoptosis of vascular smooth muscle cells (VSMCs). Resveratrol inhibited the growth of human aortic VSMCs at concentrations as low as 1 microM. This was due to the profound dose-dependent inhibition of DNA synthesis by resveratrol. DNA synthesis was more effectively inhibited when cells were pretreated with resveratrol. Resveratrol caused a dose-dependent increase in intracellular p53 and p21(WAF1 ...

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