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2332. Cardiovascular and nerve support antioxidant* Supports glucose utilization* Advanced form Na-RALA, sodium-R-lipoateR-Alpha lipoic Acid is an antioxidant for nerve integrity and heart health. We use the advanced form of R-lipoic acid, called Na-RALA or sodium-R-lipoate. It is ...
90 capsules $32.00 $25.60
Top liver and gallbladder support formula* Improves natural detoxification processes* Features chlorella, NAC, lipoic acid, milk thistleDaily Balancer? is our top nutritional formula for the liver. It supports the natural processes of detoxification.* Features...
n Protector™ contains key antioxidant nutrients to enhance protection of the brain and nervous system. Includes blueberry, mixed berry extract, r-alpha lipoic acid, and fisetin.* Brain Protector Supplement for Brain and Nerves with Blueberry extract, R-alpha lipoic acid, Fi...
90 capsules $48.00 $38.40
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News

R-alpha-lipoic acid is a versatile small molecule antioxidant, an important member of your overall antioxidant team. A new study found that
... June 8, 2013| Byron J. Richards, Board Certified Clinical Nutritionist R-alpha-lipoic acid is a versatile small molecule antioxidant, an important member of your overall antioxidant team. A new study found that treatment with lipoic acid could dramatically improve heart protection by increasing the activity of the aldehyde dehydrogenase enzyme. I will endeavor to explain the extreme importance of this study, highly relevant to any person with brain fog, chemical sensitivity, Candida albicans issues, alcohol sensitivity and related symptoms. The classic example of a toxic aldehyde is acetaldehyde ...
Type 2 diabetes is a difficult metabolic problem. It is a national embarrassment that so many of our young people are becoming type 2 diabetic. It...
... Commun. Jiang WJ.^ Resveratrol Assists Weight Loss In A Variety of Ways The Endocrine Society's 90th Annual Meeting in San Francisco.^ Resveratrol Supports Adiponectin by Reducing Inflammation Biochem Biophys Res Commun. Ahn J, Lee H, Kim S, Ha T.^ Lipoic Acid Supports Healthy Blood Sugar and Insulin Function in Diabetics Nutr Rev. Singh U, Jialal I.^ Lipoic Acid Helps Patients with Diabetic Neuropathy Bosn J Basic Med Sci. Bureković A, Terzić M, Alajbegović S, Vukojević Z, Hadzić N.^ ...
Many potential monkey wrenches wreak havoc with your metabolism and impede your ability to lose weight. New science indicates that damage to your ...
... , Moriya N, Touno E, Oshibe A, Hodate K.^ Vitamin D and Vitamin E Protect Against LPS Lipids Health Dis. Lira FS, Rosa JC, Cunha CA, Ribeiro EB, Oller do Nascimento C, Oyama LM, Mota JF.^ Lipoic Acid stops LPS-Induced Inflammatory Toxicity Proc Natl Acad Sci U S A. Zhang WJ, Wei H, Hagen T, Frei B.^ Lipoic Acid Protects Cell Energy Production from LPS Toxicity Free Radic Res. Vanasco V, Cimolai MC, Evelson P, Alvarez ...

Health Topics

Wellness Resources provides the highest quality supplements for nerve communication and heart health.
... needed for nerve transmission are B vitamins, magnesium, and calcium. Nutrients like ALC and Q10 boost the body's functions. Proper thyroid function is also important for healthy nerve transmission down long nerves. Additionally, nerves must be protected, and that is where R Alpha Lipoic Acid, RALA, comes in as it is a potent nerve antioxidant. Numerous studies show that RALA supports the integrity of healthy nerve transmission.* Normal heart function is under complex regulation from both sympathetic and parasympathetic nerves. These nerves must be able to communicate ...
Antioxidants such as lutein, lycopene, DHA, and astaxanthin help to nourish and protect eyes and support healthy vision and eyesight.
... helps support healthy ocular pressure and reduce retinal stress from nearsightedness.* 88 90 capsules $40.00 $32.00 20% off! 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 ADD TO CART ADD TO CART Lipoic Acid, R-Alpha Reduced price! In Stock R-alpha lipoic acid works with other antioxidants like zinc, selenium, and n-acetyl cysteine (in Daily Protector) to nourish delicate nerve tissues and the lining of blood vessels. It helps the body convert glucose to energy and ...
Managing the gene signal NF-kappaB is needed for bone mass and bone density. Offset the stress on bones with nutritional supplements such as querc...
... of nutrients help NF-kappaB relax, promoting healthy balance between osteoclasts and osteoblasts. Nutrients that have already demonstrated this NF-kappaB modulating function relating to osteoclast formation and osteoclast function are boswella serrata, quercetin, curcumin, guggul, DHA, tocotrienols (special vitamin E), R-alpha lipoic acid, green tea catechins, zinc, and of course magnesium.* The more stress and demands you are under, especially over an extended period of time, the more you want to be sure you don't run low on nutrients that help NF-kappaB work properly ...

Study

Lipoic Acid Synthase (LASY): A Novel Role in Inflammation, Mitochondrial Function and Insulin Resistance.
... Study Title: Lipoic Acid is Required for Energy Production and Insulin Function Study Abstract Objective: Lipoic acid synthase (LASY) is the enzyme that is involved in the endogenous synthesis of lipoic acid, a potent mitochondrial antioxidant. The aim of this study was to study the role of LASY in type 2 diabetes. Research Design and Methods: We studied expression of LASY in animal models of type 2 diabetes. We also looked at regulation of LASY in vitro under conditions that exist in diabetes. Additionally, we looked at effects ...
Lipoic acid improves glucose utilisation and prevents protein glycation and AGE formation.
... Study Title: Lipoic Acid Prevents Sugar Damage Study Abstract The present study investigates the antiglycating effect of alpha-lipoic acid (LA) in high fructose-fed rats in vivo and its potential to inhibit the process of glycation in vitro. In addition, the effect of LA on glucose utilisation in rat diaphragm was also studied. Rats fed a high fructose diet (60% total calories) were administered with 35 mg/kg b.w, lipoic acid (LA) intraperitoneally for 20 days. The effects of LA on plasma glucose, fructosamine, ...
Alpha-lipoic acid attenuates LPS-induced inflammatory responses by activating the phosphoinositide 3-kinase/Akt signaling pathway.
... Study Title: Lipoic Acid stops LPS-Induced Inflammatory Toxicity Study Abstract The phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway was recently shown to negatively regulate LPS-induced acute inflammatory responses. We previously observed that the metabolic thiol antioxidant alpha-lipoic acid (LA) inhibits LPS-induced expression of cellular adhesion molecules and adherence of monocytes to human aortic endothelial cells. Here we investigated the mechanism by which LA attenuates LPS-induced monocyte activation in vitro and acute inflammatory responses in vivo. Incubation of human monocytic THP-1 cells with LA induced phosphorylation of ...

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Products

Showing 3 of 3
2332. Cardiovascular and nerve support antioxidant* Supports glucose utilization* Advanced form Na-RALA, sodium-R-lipoateR-Alpha lipoic Acid is an antioxidant for nerve integrity and heart health. We use the advanced form of R-lipoic acid, called Na-RALA or sodium-R-lipoate. It is ...
90 capsules $32.00 $25.60
Top liver and gallbladder support formula* Improves natural detoxification processes* Features chlorella, NAC, lipoic acid, milk thistleDaily Balancer? is our top nutritional formula for the liver. It supports the natural processes of detoxification.* Features...
n Protector™ contains key antioxidant nutrients to enhance protection of the brain and nervous system. Includes blueberry, mixed berry extract, r-alpha lipoic acid, and fisetin.* Brain Protector Supplement for Brain and Nerves with Blueberry extract, R-alpha lipoic acid, Fi...
90 capsules $48.00 $38.40

News

Showing 10 of 19 View all news results >
R-alpha-lipoic acid is a versatile small molecule antioxidant, an important member of your overall antioxidant team. A new study found that
... June 8, 2013| Byron J. Richards, Board Certified Clinical Nutritionist R-alpha-lipoic acid is a versatile small molecule antioxidant, an important member of your overall antioxidant team. A new study found that treatment with lipoic acid could dramatically improve heart protection by increasing the activity of the aldehyde dehydrogenase enzyme. I will endeavor to explain the extreme importance of this study, highly relevant to any person with brain fog, chemical sensitivity, Candida albicans issues, alcohol sensitivity and related symptoms. The classic example of a toxic aldehyde is acetaldehyde ...
Type 2 diabetes is a difficult metabolic problem. It is a national embarrassment that so many of our young people are becoming type 2 diabetic. It...
... Commun. Jiang WJ.^ Resveratrol Assists Weight Loss In A Variety of Ways The Endocrine Society's 90th Annual Meeting in San Francisco.^ Resveratrol Supports Adiponectin by Reducing Inflammation Biochem Biophys Res Commun. Ahn J, Lee H, Kim S, Ha T.^ Lipoic Acid Supports Healthy Blood Sugar and Insulin Function in Diabetics Nutr Rev. Singh U, Jialal I.^ Lipoic Acid Helps Patients with Diabetic Neuropathy Bosn J Basic Med Sci. Bureković A, Terzić M, Alajbegović S, Vukojević Z, Hadzić N.^ ...
Many potential monkey wrenches wreak havoc with your metabolism and impede your ability to lose weight. New science indicates that damage to your ...
... , Moriya N, Touno E, Oshibe A, Hodate K.^ Vitamin D and Vitamin E Protect Against LPS Lipids Health Dis. Lira FS, Rosa JC, Cunha CA, Ribeiro EB, Oller do Nascimento C, Oyama LM, Mota JF.^ Lipoic Acid stops LPS-Induced Inflammatory Toxicity Proc Natl Acad Sci U S A. Zhang WJ, Wei H, Hagen T, Frei B.^ Lipoic Acid Protects Cell Energy Production from LPS Toxicity Free Radic Res. Vanasco V, Cimolai MC, Evelson P, Alvarez ...
Nutrients can activate gene metabolism within cells, not only improving the metabolism of glucose and fatty acids but doing so without any adverse...
... July 5, 2008| Byron J. Richards, Board Certified Clinical Nutritionist Nutrients can activate gene metabolism within cells, not only improving the metabolism of glucose and fatty acids but doing so without any adverse side effects. In the study researchers used R-Alpha Lipoic Acid (RLA) and Acetyl-L-Carnitine (ALC)1 as the primary nutrients tested, along with niacin and biotin (two B vitamins typically found in a multiple vitamin or B Complex) as cofactors to enhance the use of RLA and ALC. They found these nutrients dramatically ...
Hot flashes, insomnia, mood swings, memory problems, night sweats. These symptoms of perimenopause and menopause are often disruptive and distress...
... focused on the status of glutathione levels. This is the master antioxidant system in the body and requires multiple nutrients to make it work. Some of the main nutrients needed to make glutathione in the body are N-acetyl-cysteine (NAC) or the amino acid l-cysteine, R-alpha lipoic acid, zinc, copper, B vitamins, magnesium, MSM sulfur, glutamine, vitamin A, C, and E. Sulfur-rich foods and cruciferous vegetables must be included in the diet. For example asparagus, beets, green beans, broccoli, and watermelon ...
Are you struggling with fatigue? Want to sharpen your memory? Feeling like your get-up-and-go got up and went? Then your mitochondria may need a b...
... , incorporating more quality whole foods, and increasing exercise are always good places to start. However, there are certain mitochondrial boosting nutrients that can be beneficial to take as well, including protective antioxidants and energy boosting nutrients such as PQQ, astaxanthin, acetyl-L-carnitine, R-alpha lipoic acid, coenzyme Q10, magnesium, and B vitamins. Your mitochondria are constantly working to supply you with energy and probably double-time if there is a continual stressor affecting your health. These little powerhouses do so much for you, isn't it time you return the ...
Several studies published this month offer a new understanding and hope to those suffering from the ringing in the ears known as tinnitus. This co...
... move lymph stagnation that backs pressure up on the hearing mechanisms within the ear. Interestingly, that nutrient, by relieving pressure next to the brain stem is also likely to turn off inflammatory signals entering the subconscious brain. I have also used grape seed extract and R-alpha lipoic acid to help improve circulation to the ear. Once again, both of these nutrients have nerve-related anti-inflammatory properties. I've had various working theories as to why tinnitus occurs, and have seen some improvement for some (not all) following basic nutrient use. However ...
A unique brain-imaging study of identical twins and fraternal twins has shown that genes have a profound influence on the integrity of nerve cell ...
... nutrients that make phospholipids in plentiful amounts in order to facilitate the formation of these important coatings on the "nerve wires." The best nutrients for this purpose are DHA, phosphatidylserine, calcium AEP and fat-soluble antioxidants that protect phospholipid structures from damage (tocotrienols, R-alpha lipoic acid, Q10, carotenes). The enemies to intelligence come under the category of toxins, infections, and stress both during and following pregnancy and in early childhood. Fat-soluble toxins are a major problem to brain myelin sheathing. These toxins are in the air ...
Coenzyme Q10 was the first anti-aging superstar nutrient, hitting the consumer market in the 1970s. Q10's promise to turn back the clock on a...
... lot of mitochondria. Your cell engines combine fuel (calories) with oxygen, and then use various nutrients in a multistep process to produce cellular energy, known as ATP. Many nutrients assist in this function, including B vitamins, krebs cycle cofactors, magnesium, lipoic acid, acetyl-l-carnitine, and Q10. Thus, Q10 is part of your energy-producing team. It plays a very important role in the final steps of energy production, and cannot be replaced or compensated for by any other nutrient. If you have an adequate amount ...
There are a lot of great anti-aging and metabolism boosting nutrients: DHA,
... February 3, 2014| Byron J. Richards, Board Certified Clinical Nutritionist There are a lot of great anti-aging and metabolism boosting nutrients: DHA, pantethine1, acetyl-l-carnitine, carnosine, r-alpha lipoic acid, grape seed extracts the list goes on and on. In fact, most nutrients help cells function better and thus live longer. So, why is resveratrol vying for the position as King of the anti-aging nutrients with a potent fat-burning twist thrown in for good measure? Maybe we should ask Big Pharma, who is spending a ...

Health Topics

Wellness Resources provides the highest quality supplements for nerve communication and heart health.
... needed for nerve transmission are B vitamins, magnesium, and calcium. Nutrients like ALC and Q10 boost the body's functions. Proper thyroid function is also important for healthy nerve transmission down long nerves. Additionally, nerves must be protected, and that is where R Alpha Lipoic Acid, RALA, comes in as it is a potent nerve antioxidant. Numerous studies show that RALA supports the integrity of healthy nerve transmission.* Normal heart function is under complex regulation from both sympathetic and parasympathetic nerves. These nerves must be able to communicate ...
Antioxidants such as lutein, lycopene, DHA, and astaxanthin help to nourish and protect eyes and support healthy vision and eyesight.
... helps support healthy ocular pressure and reduce retinal stress from nearsightedness.* 88 90 capsules $40.00 $32.00 20% off! 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 ADD TO CART ADD TO CART Lipoic Acid, R-Alpha Reduced price! In Stock R-alpha lipoic acid works with other antioxidants like zinc, selenium, and n-acetyl cysteine (in Daily Protector) to nourish delicate nerve tissues and the lining of blood vessels. It helps the body convert glucose to energy and ...
Managing the gene signal NF-kappaB is needed for bone mass and bone density. Offset the stress on bones with nutritional supplements such as querc...
... of nutrients help NF-kappaB relax, promoting healthy balance between osteoclasts and osteoblasts. Nutrients that have already demonstrated this NF-kappaB modulating function relating to osteoclast formation and osteoclast function are boswella serrata, quercetin, curcumin, guggul, DHA, tocotrienols (special vitamin E), R-alpha lipoic acid, green tea catechins, zinc, and of course magnesium.* The more stress and demands you are under, especially over an extended period of time, the more you want to be sure you don't run low on nutrients that help NF-kappaB work properly ...
Naturally improve your liver and pancreas health with these important nutrients. Help your liver and pancreas to function optimally.
... Improve Your Liver and Pancreas Health In order to sustain healthy blood sugar and insulin function it is vital to ensure your liver is in excellent working condition. Various nutrients, like silymarin, R-alpha lipoic acid, NAC, pantethine, acetyl-l-carnitine, and carnosine support the healthy metabolism of fat and sugar by your liver. Various herbs, such as gymnema sylvestre, pterocarpus marsupium, and bitter melon have a nutritionally rejuvenating effect on your pancreas.* These types of nutrients can be added for protective support, as well as to assist ...
Naturally improve detoxification with Wellness Resources liver health supplements. Combat environmental chemicals, toxins in food, and digestive t...
... liver, detox, detoxification, sulfur, silymarin, chlorella, lipoic acid, r-alpha lipoic acid, pantethine, aldehyde, chemical sensitivities, fiber, immune, detox, supplements, liver health, clear toxins, pollution, constipation ...
The healthy function of the digestive system is vital in clearing toxins from the body.
... liver, detox, detoxification, sulfur, silymarin, chlorella, lipoic acid, r-alpha lipoic acid, pantethine, aldehyde, chemical sensitivities, fiber, immune, arabinogalactin, protein, oat beta-glucan, gi tract, waste, clear toxins, pollution, constipation ...
Wellness Resources liver supplements support daily detoxification of environmental chemicals, chemical sensitivities, food chemicals, and digestiv...
... liver, detox, detoxification, sulfur, silymarin, chlorella, lipoic acid, r-alpha lipoic acid, pantethine, aldehyde, chemical sensitivities, fiber, immune, arabinogalactin, protein, oat beta-glucan, gi tract, waste, clear toxins, pollution, constipation ...
Wellness Resources liver supplements support daily detoxification of environmental chemicals, chemical sensitivities, food chemicals, and digestiv...
... liver, detox, detoxification, sulfur, silymarin, chlorella, lipoic acid, r-alpha lipoic acid, pantethine, aldehyde, chemical sensitivities, fiber, immune, arabinogalactin, protein, oat beta-glucan, gi tract, waste, clear toxins, pollution, constipation ...
Wellness Resources high quality brain supplements improve memory, build healthy brain cells, and improve focus and coordination.
... ADD TO CART Brain Protector™ Reduced price! In Stock Support memory, brain and nerve health. Brain Protector™ contains four potent nerve and brain protecting nutrients to help you maintain healthy cognitive function. These nutrients — wild blueberry extract, mixed berry extract, r-alpha lipoic acid, and fisetin — help protect nerves, participate as part of a synergistic antioxidant network, and improve memory and cognitive function. The nutrients in Brain Protector™ also enhance the natural process of autophagy, helping to clear toxins from brain cells. Protect your ...
Wellness Resources rejuvenation supplements provide excellent support for optimal cellular health.
... a great nutrient to assist pain management. Other good cell membrane nutrients include essential fatty acids like DHA(cardiovascular and mood health), and phosphatidyl serine (memory and stress tolerance). Fat soluble antioxidants help protect cell membranes (like tocotrienols, Q10, and lipoic acid), and are not discussed in this section. Calcium AEP is 10% calcium bound to 90% Amino Ethanol Phosphate (AEP, also known as colamine phosphate). It is the AEP part that gives this product its unique characteristics. AEP is ...
Lipoic Acid Synthase (LASY): A Novel Role in Inflammation, Mitochondrial Function and Insulin Resistance.
... Study Title: Lipoic Acid is Required for Energy Production and Insulin Function Study Abstract Objective: Lipoic acid synthase (LASY) is the enzyme that is involved in the endogenous synthesis of lipoic acid, a potent mitochondrial antioxidant. The aim of this study was to study the role of LASY in type 2 diabetes. Research Design and Methods: We studied expression of LASY in animal models of type 2 diabetes. We also looked at regulation of LASY in vitro under conditions that exist in diabetes. Additionally, we looked at effects ...
Lipoic acid improves glucose utilisation and prevents protein glycation and AGE formation.
... Study Title: Lipoic Acid Prevents Sugar Damage Study Abstract The present study investigates the antiglycating effect of alpha-lipoic acid (LA) in high fructose-fed rats in vivo and its potential to inhibit the process of glycation in vitro. In addition, the effect of LA on glucose utilisation in rat diaphragm was also studied. Rats fed a high fructose diet (60% total calories) were administered with 35 mg/kg b.w, lipoic acid (LA) intraperitoneally for 20 days. The effects of LA on plasma glucose, fructosamine, ...
Alpha-lipoic acid attenuates LPS-induced inflammatory responses by activating the phosphoinositide 3-kinase/Akt signaling pathway.
... Study Title: Lipoic Acid stops LPS-Induced Inflammatory Toxicity Study Abstract The phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway was recently shown to negatively regulate LPS-induced acute inflammatory responses. We previously observed that the metabolic thiol antioxidant alpha-lipoic acid (LA) inhibits LPS-induced expression of cellular adhesion molecules and adherence of monocytes to human aortic endothelial cells. Here we investigated the mechanism by which LA attenuates LPS-induced monocyte activation in vitro and acute inflammatory responses in vivo. Incubation of human monocytic THP-1 cells with LA induced phosphorylation of ...
Lipoic Acid Inhibits Inflammatory Bone Resorption by Suppressing Prostaglandin E2 Synthesis.
... Study Title: Lipoic Acid Helps Prevent Bone Loss Study Abstract-Lipoic acid (LA) has been intensely investigated as a therapeutic agent for several pathological conditions, including diabetic polyneuropathy. In the present study, we examined the effects of LA on osteoclastic bone loss associated with inflammation. LA significantly inhibited IL-1-induced osteoclast formation in cocultures of mouse osteoblasts and bone marrow cells, but LA had only a marginal effect on osteoclastogenesis from bone marrow macrophages induced by receptor activator of NF-B ligand (RANKL). LA inhibited both the sustained up-regulation ...
Alpha-lipoic acid supplementation and diabetes.
... Study Title: Lipoic Acid Supports Healthy Blood Sugar and Insulin Function in Diabetics Study Abstract Diabetes is a common metabolic disorder that is usually accompanied by increased production of reactive oxygen species or by impaired antioxidant defenses. Importantly, oxidative stress is particularly relevant to the risk of cardiovascular disease. Alpha-lipoic acid (LA), a naturally occurring dithiol compound, has long been known as an essential cofactor for mitochondrial bioenergetic enzymes. LA is a very important micronutrient with diverse pharmacologic and antioxidant properties. Pharmacologically, LA improves glycemic control and polyneuropathies ...
THE role of alpha-lipoic acid in diabetic polyneuropathy treatment..
... Study Title: Lipoic Acid Helps Patients with Diabetic Neuropathy Study Abstract Diabetic neuropathy represents late diabetes complications, and diabetes duration and long-term hyperglycemia are the main reasons for polyneuropathy. The goal was to estimate the effects of alpha-lipoic acid on symptoms of diabetic neuropathy after 600 mg i.v. for 3 weeks and 3 months of 300-600 mg of alpha-lipoic acid per os. This study has been designed as a multicentric, in 5-centers in B&H, carried out by 5 physicians with 20 diabetic patients each. Following parameters were monitored in ...
The oxidative stress and the mitochondrial dysfunction caused by endotoxemia are prevented by alpha-lipoic acid.
... Study Title: Lipoic Acid Protects Cell Energy Production from LPS Toxicity Study Abstract The aims of this work were to study the mitochondrial function and to evaluate (a) the oxidative stress in real time in an acute model of endotoxemia and (b) the effect of alpha-lipoic acid (LA, 100 mg/kg) as a therapeutic strategy to be considered. In rats treated with lipopolisaccharide (LPS, 10 mg/kg), a 1.4-fold increase was observed in in situ skeletal muscle chemiluminescence. Experimental sepsis increased oxygen consumption ...
Prophylaxis with alpha-lipoic acid against lipopolysaccharide-induced brain injury in rats.
... Study Title: Lipoic Acid Protects Brain from LPS Toxicity Study Abstract INTRODUCTION: Lipopolysaccharide (LPS) stimulates the synthesis and release of reactive oxygen species that play an important role in the pathogenesis of tissue injuries. In this study the effect of early administration of the antioxidant alpha-lipoic acid (alpha-LA) on brain lipid peroxidation, brain hydrogen peroxide (H (2 )O (2 )) concentration, and brain total sulfhydryl group( -SH group) content was evaluated in rats with endotoxic shock induced by administration of LPS ( ...
Effect of alpha-lipoic acid on LPS-induced oxidative stress in the heart.
... Study Title: Lipoic Acid Protects the Heart from LPS Toxicity Study Abstract Lipopolysaccharide (LPS) is a gram-negative bacterial endotoxin and a major factor that contributes to multiple organ failure, including heart injury. Myocardial dysfunction in septic shock depends on the presence of proinflammatory cytokines and reactive oxygen/nitrogen species. In this study, the effect of early administration of an antioxidant, alpha-lipoic acid (LA) on lipid peroxidation, hydrogen peroxide (H (2 )O (2 )), sulphydryl groups( -SH groups) and ...
Alpha-lipoic acid ameliorates oxidative stress by increasing aldehyde dehydrogenase-2 activity in patients with acute coronary syndrome.
... Study Title: Lipoic Acid and Acetaldehyde Study Abstract Aldehyde dehydrogenase-2 (ALDH2) is the main enzyme responsible for acetaldehyde oxidation in ethanol metabolism and also provides protection against oxidative stress. Alpha-lipoic acid (α-LA), a natural dithiol compound with antioxidant properties, has been reported to increase ALDH2 activity in cultured cells. We analyzed the therapeutic efficacy of α-LA in 63 patients with confirmed acute coronary syndrome (ACS). These patients (52 men and 11 women, with age range 49-72 years) were randomized into two groups: untreated ...

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