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and brain health*Grape Seed Extract supports the strength of tissues throughout the body. Wellness Resources provides the highest quality red grape seed extract.* grape seed extract Supplement, 92% OPC | Wellness Resources Wellness Resources grape seed...
90 capsules $19.00 $15.20
leg circulation and vein health* Improves oxygen utilization during exercise* Enhances weight management efforts* Features resveratrol and grape seed extract polyphenolsCardio Helper? is our premier nutritional supplement to support circulation, strengthen the cardiovascular system, and promote heal...
90 capsules $42.00 $33.60
2582. Nourish and revitalize skin* Strengthen and build collagen* Antioxidants for skin protection* Strengthen connective tissues* Improve natural skin moisture*Skin Rejuvenator™ contains key nutrients to improve skin elasticity and moisture, strengthen collagen, and ...
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Showing 3 of 611 View all news results >
Want firm, youthful skin? Grape seed extract has a unique collagen-strengthening effect that goes beyond skin deep!
... update your browser to a recent version or update your Flash plugin. This Week's Health Podcast Grape seed extract (GSE) is one of nature's most versatile nutrients, acting as a ... , artery, and heart strengthener, while providing potent antioxidant and anti-inflammatory activity. I have previously reviewed these attributes in my feature-length article, Grape Seed Extract's Powerful Cardio Protection. A ... of recent studies show GSE to increase collagen strength within teeth-- something the dental industry is considering using for better adhesion of composite resin to the dentin of teeth2. These studies ...
Several new studies are demonstrating a potent energetic improvement in muscles following supplementation with grape seed extract. These animal st...
... Week's Health Podcast Several new studies are demonstrating a potent energetic improvement in muscles following supplementation with grape seed extract. These animal studies are unique as they are able to document which genes ... getting activated, helping to prove the molecular function of grape seed extract to enhance energy production and exercise ability. In the first study rats were fasted for 14 hours and then fed ... , either with or without grape seed extract1. Gene expression was studied in their muscles, liver, and brown adipose tissue. After 5 hours, those fed grape seed extract had ...
Use grape seed extract as a nutritional strategy to help remineralize your teeth; this would help strengthen them so they are more resistant to ca...
... recent version or update your Flash plugin. This Week's Health Podcast A new study demonstrates that grape seed can help with the remineralization of teeth. This would help strengthen teeth and increase ... resistance to cavities. Teeth are porous by nature. Imbalanced bacteria in the mouth can produce excess acid, which can lead to pore enlargement and loss of minerals from the tooth structure ... study, human tooth sections were exposed to various substances, one of which was grape seed extract. The tooth sections were placed in acid solutions (promoting demineralization) and neutral solutions ...

Health Topics

Friendly nitric oxide helps relax the circulatory system. Supplements with grape seed extract and ginseng promote nitric oxide production.
... oxide synthase (NOS). Performa Plus provides the arginine as well as two nutrients, grape seed extract and panex ginseng that have been proven to activate the NOS enzyme. Additionally ... grape seed extract is a well known cardiovascular antioxidant which also supports the integrity of the collagen that comprises the circulatory system and heart. The flexibility of collagen is vital to healthy arteries ... Grape seed extract has numerous studies showing it directly offsets heart-related wear and tear.* ADD TO CART Lipid Helper™ Reduced price! In Stock Contains a non-flushing form of niacin, ...
Wellness Resources rejuvenation supplements provide nutritional support for healthy skin, joints, and overall body structure.
... disulfide bonds) hold your collagen fibers together. Nutrients like MSM sulfur and bioflavonoids such as grape seed proanthocyanidins naturally support these bonds, helping to maintain the natural strength and flexibility of ... . In comparison, Hyalauronic Acid (previous section) is the flexible goo that fills in between the collagen strands, as well as acting as the foundation or template of the various ... Rejuvenator™ that participate in antioxidant processes are lycopene, green tea polyphenols, and grape seed extracts. We use only the highest potency standardized extracts to ensure optimal results. Lycopene is ...
Wellness Resources rejuvenation supplements provide nutritional support for healthy skin, hair, nails, joints, and overall body structure. Natural...
... connective tissue formation and the structural integrity of collagen, including glucosamine, MSM sulfur, and grape seed proanthocyanidins. These nutrients support formation of new tissue as well as strengthening existing tissue ... may have been stressed. Also included are the special antioxidant nutrients lycopene and green tea, known to help protect your skin from chemicals and sun exposure.* 20% off! ... 12 13 14 15 16 17 18 19 20 ADD TO CART ADD TO CART Grape Seed Extract 100 Reduced price! In Stock Grape Seed Extract 100 contains red grape seed extract, ...

Study

Induction of Apoptosis in Human Leukemia Cells by Grape Seed Extract Occurs via Activation of c-Jun NH2-Terminal Kinase.
... Study Title: Grape Seed Extract and Blood Cell Cancer Study Abstract Purpose: To characterize the functional role of c-Jun NH2-terminal kinase (JNK) and other apoptotic pathways in grape seed ... (GSE) -induced apoptosis in human leukemia cells by using pharmacologic and genetic approaches.Experimental Design: Jurkat cells were treated with various concentrations of GSE for 12 and 24 h or with ... µg/mL GSE for various time intervals, after which apoptosis, caspase activation, and cell signaling pathways were evaluated. Parallel studies were done in U937 and HL-60 human leukemia cells.Results ...
Grape seed and skin extract alleviates high-fat diet-induced renal lipotoxicity and prevents copper depletion in rat.
... Study Title: Grape Seed Extract Protects Kidneys Study Abstract Obesity is a public health problem that contributes to morbidity and mortality from diabetes, heart disease, stroke, and cancers. ... purpose of this investigation was to analyse the link between obesity-induced oxidative stress, renal steatosis, and kidney dysfunction, as well as the protective effect of grape seed and skin extract. ... were fed a standard diet or a high-fat diet for 6 weeks and were either treated or not treated with grape seed and skin extract. Fat-induced oxidative stress was evaluated in the kidney ...
Catechin and proanthocyanidin B4 from grape seeds prevent doxorubicin-induced toxicity in cardiomyocytes.
... Study Title: Grape Seed Extract Protects Heart from Extreme Toxicity Study Abstract The clinical use of doxorubicin, a highly active anticancer drug, is limited by its severe cardiotoxic side effects ... Grape seed extract has been reported to exert protective effects on doxorubicin-induced cardiotoxicity. The cardiovascular protective effects of grape seed extract are believed to be ascribed to its antioxidative properties. A series ... studies have has demonstrated that polyphenols are instrumental for the antioxidative properties of grape seed extract. This study was designed to investigate whether two major polyphenols isolated from grape seed extract, catechin ...

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Products

Showing 9 of 9
and brain health*Grape Seed Extract supports the strength of tissues throughout the body. Wellness Resources provides the highest quality red grape seed extract.* grape seed extract Supplement, 92% OPC | Wellness Resources Wellness Resources grape seed...
90 capsules $19.00 $15.20
leg circulation and vein health* Improves oxygen utilization during exercise* Enhances weight management efforts* Features resveratrol and grape seed extract polyphenolsCardio Helper? is our premier nutritional supplement to support circulation, strengthen the cardiovascular system, and promote heal...
90 capsules $42.00 $33.60
2582. Nourish and revitalize skin* Strengthen and build collagen* Antioxidants for skin protection* Strengthen connective tissues* Improve natural skin moisture*Skin Rejuvenator™ contains key nutrients to improve skin elasticity and moisture, strengthen collagen, and ...
support circulation, energy, and stamina.* Performa Plus Supplement for Circulation, Energy, Stamina Performa Plus contains l-arginine, ginseng, and grape seed extract to enhance the production of friendly nitric oxide (eNOS), a natural way to support healthy circulation, energy, stamina, and sex drive.
90 capsules $29.00 $23.20
Rejuvenation Pack contains high quality nutrients for joints, skin, collagen, repair, and rejuvenation. Includes hyaluronic acid, curcumin, boswellia, grape seed extract, and more.
60 packets $149.00 $119.20
18954. Boost memory and cognitive function* Help protect nerves and brain* Help stabilize glial cells* Enhance nerve communication and gene regulation* 25% off in August!Brain Protector™ contains key antioxidant nutrients to enhance protection of the brain and n...
90 capsules $48.00 $36.00
31000. Protect and revitalize skin and connective tissues* Strengthen collagen and joints with key repair nutrients* Hydrate the skin for health and vibrancy* Includes Skin Rejuvenator™, Hyaluronic Acid, and SqualeneThe Skin Revitalize Package provides top...
$117.00 $87.75
163025. Top supplements for cholesterol metabolism, blood pressure, and circulation* Convenient, on-the-go packets Comprehensive combination of nutrients for cardiovascular health*The LeptiCardio Pack™ contains top cardiovascular health supplements in convenient o...
60 packets $183.00 $146.40
16267. Improve sex drive and stamina* Support testosterone production* Support prostate health* Improve circulation* Includes Male Plus™, Performa Plus™, and Saw PalmettoThe Male Support Package contains top supplements to naturally support men’s health, testosterone ...
$85.00 $63.75

News

Showing 10 of 611 View all news results >
Want firm, youthful skin? Grape seed extract has a unique collagen-strengthening effect that goes beyond skin deep!
... update your browser to a recent version or update your Flash plugin. This Week's Health Podcast Grape seed extract (GSE) is one of nature's most versatile nutrients, acting as a ... , artery, and heart strengthener, while providing potent antioxidant and anti-inflammatory activity. I have previously reviewed these attributes in my feature-length article, Grape Seed Extract's Powerful Cardio Protection. A ... of recent studies show GSE to increase collagen strength within teeth-- something the dental industry is considering using for better adhesion of composite resin to the dentin of teeth2. These studies ...
Several new studies are demonstrating a potent energetic improvement in muscles following supplementation with grape seed extract. These animal st...
... Week's Health Podcast Several new studies are demonstrating a potent energetic improvement in muscles following supplementation with grape seed extract. These animal studies are unique as they are able to document which genes ... getting activated, helping to prove the molecular function of grape seed extract to enhance energy production and exercise ability. In the first study rats were fasted for 14 hours and then fed ... , either with or without grape seed extract1. Gene expression was studied in their muscles, liver, and brown adipose tissue. After 5 hours, those fed grape seed extract had ...
Use grape seed extract as a nutritional strategy to help remineralize your teeth; this would help strengthen them so they are more resistant to ca...
... recent version or update your Flash plugin. This Week's Health Podcast A new study demonstrates that grape seed can help with the remineralization of teeth. This would help strengthen teeth and increase ... resistance to cavities. Teeth are porous by nature. Imbalanced bacteria in the mouth can produce excess acid, which can lead to pore enlargement and loss of minerals from the tooth structure ... study, human tooth sections were exposed to various substances, one of which was grape seed extract. The tooth sections were placed in acid solutions (promoting demineralization) and neutral solutions ...
Grape seed extract is an antioxidant shown to strengthen vascular structure, assist fat metabolism, and protect heart cells.
... February 8, 2016 Grapes are a sweet treat that many Americans enjoy eating. The seed of the grape is the most valuable part! Grape seeds are rich in bioactive compounds ... as proanthocyanidins or OPC's. These compounds play an important role in protecting the heart and improving circulation. Supplementing with grape seed extract benefits cardiovascular health by strengthening vascular structure, regulating blood ... , assisting in fat and cholesterol metabolism and providing antioxidant protection for heart cells. Grape Seed Extract and Vascular Integrity Proanthocyanidins found in grape seed extract have a very strong affinity for collagen ...
300 mg of grape seed extract per day given to patients with mild or early stage high blood pressure for four months, when combined with diet and l...
... to a recent version or update your Flash plugin. This Week's Health Podcast 300 mg of grape seed extract per day given to patients with mild or early stage high blood pressure for ... months, when combined with diet and lifestyle modifications (no medications), helped restore normal blood pressure to 93% of patients. The study group was composed of women aged 45 ... 55. The average blood pressure in the group was 150/90, and participants were in generally good health. The group was divided into three subgroups, all of which did ...
New research shows that grape seed extract is a potent disrupter of viral infection.
... a recent version or update your Flash plugin. This Week's Health Podcast New research shows that grape seed extract damages the coating on viruses, thereby preventing it from adhering to cells and ... them. This is a general anti-viral property of significance. Researchers who were looking for ways to stop norovirus, which causes more than half the foodborne illnesses in the United States each ... , made this discovery. Even low dose exposure to grape seed extract deformed a variety of viruses, rendering them too damaged to infect. I find this study particularly interesting as I ...
Grape seed extract was shown to significantly lower blood pressure in patients with metabolic syndrome, offering a common sense approach to help r...
... , Department of Internal Medicine demonstrated that doses of 150 mg and 300 mg per day of grape seed extract1 significantly lowered blood pressure in patients with metabolic syndrome. Earlier grape seed extract ... has shown that this natural extract can activate the production of friendly nitric oxide (eNOS) by turning on the enzyme (nitric oxide synthase) that helps to make it. This ... a relaxing effect in the arteries, helping blood flow more easily. Researchers tested 27 adults with metabolic syndrome over a four week period. Both 150 mg and 300 mg grape seed ...
Are you carb intolerant? Studies show grape seed extract can reduce carb-related weight gain and blood sugar spiking.
... a high carbohydrate meal with placebo, or a dose of either 100 mg or 300 mg grape seed extract (a concentrated source of grape polyphenols). Both doses of grape seed ... improved carbohydrate metabolism for the next several hours. The researchers concluded, "Grape seed extract markedly reduces postprandial plasma glucose in healthy participants after consuming a high carbohydrate meal, which suggests ... may be a useful addition to other strategies aimed to prevent development of diabetes in the healthy population." Another study provided a mixture of grape polyphenols over an eight-week period to overweight ...
Red grape seed extracts (GSE) are a powerful cardioprotective compound. They strengthen your arteries/capillaries, and offer dramatic antioxidant ...
... February 4, 2013| Byron J. Richards, Board Certified Clinical Nutritionist Red grape seed extracts (GSE) are a powerful cardioprotective compound. They strengthen your arteries/capillaries ... and offer rather dramatic antioxidant protection for your arteries and heart. Also, through a number of mechanisms they reduce the likelihood that plaque will form in your arteries. New molecular science ... that the effects of GSE are much more diverse than previously understood. GSE works actively at the gene transcription level to promote changes favorable to cardiovascular health that include reducing inflammation and improving ...
A review of the current science on grape seed extract and grapes by University of Colorado Cancer Center states, “Overall, completed stu...
... | Byron J. Richards, Board Certified Clinical Nutritionist A review of the current science on grape seed extract and grapes by University of Colorado Cancer Center1 states, "Overall, completed ... from various scientific groups conclude that both grapes and grape-based products are excellent sources of various anticancer agents and their regular consumption should thus be beneficial to the general population." It is ... that societies eating larger amounts of fresh fruit and vegetables have less cancer. Grape seed extracts are one of many concentrated phytonutrients that reduce how cancer starts, grows, and spreads. ...

Health Topics

Friendly nitric oxide helps relax the circulatory system. Supplements with grape seed extract and ginseng promote nitric oxide production.
... oxide synthase (NOS). Performa Plus provides the arginine as well as two nutrients, grape seed extract and panex ginseng that have been proven to activate the NOS enzyme. Additionally ... grape seed extract is a well known cardiovascular antioxidant which also supports the integrity of the collagen that comprises the circulatory system and heart. The flexibility of collagen is vital to healthy arteries ... Grape seed extract has numerous studies showing it directly offsets heart-related wear and tear.* ADD TO CART Lipid Helper™ Reduced price! In Stock Contains a non-flushing form of niacin, ...
Wellness Resources rejuvenation supplements provide nutritional support for healthy skin, joints, and overall body structure.
... disulfide bonds) hold your collagen fibers together. Nutrients like MSM sulfur and bioflavonoids such as grape seed proanthocyanidins naturally support these bonds, helping to maintain the natural strength and flexibility of ... . In comparison, Hyalauronic Acid (previous section) is the flexible goo that fills in between the collagen strands, as well as acting as the foundation or template of the various ... Rejuvenator™ that participate in antioxidant processes are lycopene, green tea polyphenols, and grape seed extracts. We use only the highest potency standardized extracts to ensure optimal results. Lycopene is ...
Wellness Resources rejuvenation supplements provide nutritional support for healthy skin, hair, nails, joints, and overall body structure. Natural...
... connective tissue formation and the structural integrity of collagen, including glucosamine, MSM sulfur, and grape seed proanthocyanidins. These nutrients support formation of new tissue as well as strengthening existing tissue ... may have been stressed. Also included are the special antioxidant nutrients lycopene and green tea, known to help protect your skin from chemicals and sun exposure.* 20% off! ... 12 13 14 15 16 17 18 19 20 ADD TO CART ADD TO CART Grape Seed Extract 100 Reduced price! In Stock Grape Seed Extract 100 contains red grape seed extract, ...
Resveratrol, grape seed extract, and hawthorne, and horse chestnut are nutrients that support heart health and integrity of the arteries, veins, a...
... leaky capillaries, thus supporting healthy blood pressure fitness.* Cardio Helper™ contains resveratrol, grape seed extract, hawthorn berry and horse chestnut, four powerful nutrients that nourish the lining ... the arteries and capillaries so that their integrity is enhanced. This helps keep water correctly within the circulation and thus helps maintain correct blood pressure.* ADD TO CART Cardio Helper™ ... price! In Stock Cardio Helper™ includes the finest quality extracts of trans resveratrol, grape seed extracts, hawthorn, and horsechestnut. It is designed to support and enhance circulatory integrity ...
Appetite is important for keeping energy levels up and health strong.
... nutrients to promote digestive vitality in this situation are Daily DHA (essential fatty acids), Grape Seed Extract, Quercetin (bioflavonoids), and zinc (Strengthener Plus). Extra ... often enables a return of appetite, but some caution is needed because it can at times make a person nauseous.* ADD TO CART Daily Protein Plus™ Reduced price! In ... The finest quality whey protein (contains no lactose) can be used to boost the protein energy nutrition in any person with weakened digestion. It also contains oat beta glucan fiber and ...
Give your skin the nutrition it needs! These are the best supplements for healthy, youthful skin. Includes hyaluronic acid, VERISOL collagen, grap...
... ceramides to help strengthen collagen and revitalize skin. Skin Rejuvenator™ also contains MSM sulfur, grape seed extract, green tea extract, and lycopene. This excellent combination of nutrients is ... to help improve skin elasticity and moisture, build collagen, and protect the skin.*The nutrients in Skin Rejuvenator™ feed the dermis, or middle layer of the skin, ... makes up 90% of the skin's thickness and is abundant in collagen. The nutrients have been shown to improve skin smoothness and hydration, reduce cellulite, and reduce fine wrinkles. ...
New science shows bones regulate blood sugar. Improve metabolism, blood sugar, bone density, and weight gain. Osteoblast and osteoclast function i...
... production include vitamin D, DHA, magnesium, zinc, quercetin, curcumin, colostrum, grape seed extract, resveratrol, and mangosteen.* Interestingly, many of these same nutrients ... also been shown to support healthy osteoblast and osteoblast balance, lending to the theory that they may boost adiponectin production by assisting osteocalcin production (something that hasn't been demonstrated yet because nobody ... thought to look at the connection) .* The bottom line message is that anything you can do to improve your metabolism is likely to improve your bone health and anything you do ...
Wellness Resources cellulite supplements can greatly help reduce visible cellulite.
... is Skin Rejuvenator. It contains the excellent skin antioxidants of green tea, lycopene, and grape seed extract along with the tissue strengthening nutrients glucosamine, MSM Sulfur and once again the ... seed extract. Additional helpful information on rejuvenating your body can be found on the Rejuvenation health topic page.* ADD TO CART Repair Plus™ Reduced price! In Stock This product ... your body to make these enzymes declines with age and/or fatigue. Thankfully, natural extracts from fruits like pineapple (bromelain) and papaya (papain) can provide a boost ...
Wellness Resources postpartum supplements can help your child start his or her life with a healthy digestive and immune system.
... we have used for many years in this regard are GI Soother, Immune Plus, and Grape Seed Extract. They can be used to help calm a colicky baby or improve any ... digestive symptoms like foul smelling stools or other digestive issues. All three of these are very gentle and non-toxic in any amount-- yet effective at really helping digestion and immunity. ... may be used on a regular basis as part of a healthy diet or as needed to help overcome digestive challenges.* ADD TO CART Immune Plus™ Reduced price! In Stock ...
Wellness Resources cellulite supplements can greatly help reduce visible cellulite.
... 10 11 12 13 14 15 16 17 18 19 20 ADD TO CART ADD TO CART Grape Seed Extract 100 Reduced price! In Stock Highest quality grape seed proanthocyanadins. This vital ... of fruit participates in the antioxidant process and helps protect the nervous system from stress.* Each capsule contains 100 mg; use 0.5 mg per pound of body weight to supplement the ... . 134 90 capsules $19.00 $15.20 20% off! 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 ADD TO ...
Induction of Apoptosis in Human Leukemia Cells by Grape Seed Extract Occurs via Activation of c-Jun NH2-Terminal Kinase.
... Study Title: Grape Seed Extract and Blood Cell Cancer Study Abstract Purpose: To characterize the functional role of c-Jun NH2-terminal kinase (JNK) and other apoptotic pathways in grape seed ... (GSE) -induced apoptosis in human leukemia cells by using pharmacologic and genetic approaches.Experimental Design: Jurkat cells were treated with various concentrations of GSE for 12 and 24 h or with ... µg/mL GSE for various time intervals, after which apoptosis, caspase activation, and cell signaling pathways were evaluated. Parallel studies were done in U937 and HL-60 human leukemia cells.Results ...
Grape seed and skin extract alleviates high-fat diet-induced renal lipotoxicity and prevents copper depletion in rat.
... Study Title: Grape Seed Extract Protects Kidneys Study Abstract Obesity is a public health problem that contributes to morbidity and mortality from diabetes, heart disease, stroke, and cancers. ... purpose of this investigation was to analyse the link between obesity-induced oxidative stress, renal steatosis, and kidney dysfunction, as well as the protective effect of grape seed and skin extract. ... were fed a standard diet or a high-fat diet for 6 weeks and were either treated or not treated with grape seed and skin extract. Fat-induced oxidative stress was evaluated in the kidney ...
Catechin and proanthocyanidin B4 from grape seeds prevent doxorubicin-induced toxicity in cardiomyocytes.
... Study Title: Grape Seed Extract Protects Heart from Extreme Toxicity Study Abstract The clinical use of doxorubicin, a highly active anticancer drug, is limited by its severe cardiotoxic side effects ... Grape seed extract has been reported to exert protective effects on doxorubicin-induced cardiotoxicity. The cardiovascular protective effects of grape seed extract are believed to be ascribed to its antioxidative properties. A series ... studies have has demonstrated that polyphenols are instrumental for the antioxidative properties of grape seed extract. This study was designed to investigate whether two major polyphenols isolated from grape seed extract, catechin ...
Polyphenolics in grape seeds-biochemistry and functionality.
... Study Title: The Collagen Strengthening Properties of Grape Seed Extract Study Abstract Grape seeds are waste products of the winery and grape juice industry. These seeds contain lipid, protein, ... , and 5-8% polyphenols depending on the variety. Polyphenols in grape seeds are mainly flavonoids, including gallic acid, the monomeric flavan-3-ols catechin, epicatechin, gallocatechin, epigallocatechin, and ... 3-O-gallate, and procyanidin dimers, trimers, and more highly polymerized procyanidins. Grape seed extract is known as a powerful antioxidant that protects the body from premature aging, disease, and ...
Grape seed extract and zinc containing nutritional food supplement prevents onset and progression of age-related cataract in wistar rats.
... Study Title: Grape seed extract and zinc containing nutritional food supplement prevents onset and progression of Study Abstract OBJECTIVE:To study possible inhibition of oxidative stress and cataract formation by single ... formulation of grape seed extract and Zincovit tablets against sodium selenite-induced age-related cataract in Wistar rat pups. METHODS:Oxidative stress and consequent cataract formation was induced by subcutaneous administration of a single ... of sodium selenite (10 µmoles/kg) to Wistar rat pups on day 7 post-natally. In experiments designed to inhibit such cataract formation, the pups were pretreated subcutaneously with combined ...
Grape seed polyphenols and curcumin reduce genomic instability events in a transgenic mouse model for Alzheimer's disease.
... Study Title: Grape Seed Extract and Curcumin Improve Telomere Length, Protect Genome Study Abstract The study set out to determine (a) whether DNA damage is elevated in mice that ... mutations in the amyloid precursor protein (APP695swe) and presenilin 1 (PSEN1-dE9) that predispose to Alzheimer's disease (AD) relative to non-transgenic control mice, and (b) whether ... the intake of dietary polyphenols from curcumin or grape seed extract could reduce genomic instability events in a transgenic mouse model for AD. DNA damage was measured using the micronucleus (MN) ...
Mechanism of the endothelium-dependent relaxation evoked by a grape seed extract.
... Study Title: Grape Seed Extract Helps Relax Your Circulation Study Abstract GSEs (grape seed extracts) which contain polyphenolic compounds cause an endothelium-dependent relaxation of blood vessels. The aim of ... present study was to examine the mechanisms involved in this response. A well-characterized GSE was applied to rabbit aortic rings suspended in organ baths containing Krebs-Henseleit buffer maintained at 37 degrees C. ... aortic rings pre-contacted with noradrenaline (norepinephrine), the extract produced a dose-dependent relaxation. The maximum relaxations elicited by the extract (71.9+/ -1.0%) were similar to ...
Grape seed and skin extracts inhibit platelet function and release of reactive oxygen intermediates.
... Study Title: Grape Seed Extracts Reduce Platelet Stickiness Study Abstract Red wine and purple grape juice contain polymeric flavonoids with antioxidant properties believed to be protective against cardiovascular events but the alcohol ... sugar content of these beverages has curtailed their medicinal use. Acute cardiac events are also associated with enhanced inflammation and thrombosis. In this study, the extracts from grape skins or seeds ... examined for their anti-inflammatory properties and effect on platelet release of reactive oxygen intermediates. Incubation of platelets with seed or skin extract led to a decrease in platelet aggregation from 68.8+/ ...
Effect of grape seed extract on blood pressure in subjects with the metabolic syndrome.
... Study Title: Grape Seed Extract Lowers Blood Pressure in Metabolic Syndrome Study Abstract This study was undertaken to determine whether grape seed extracts (GSE) that contain powerful vasodilator phenolic compounds ... blood pressure in subjects with the metabolic syndrome. The subjects were randomized into 3 groups-(a) placebo, (b) 150 mg GSE per day, and (c ... 300 mg GSE per day-and treated for 4 weeks. Serum lipids and blood glucose were measured at the beginning of the study and at the end. Blood pressure was recorded using an ...
Vasodilating procyanidins derived from grape seeds.
... Study Title: Grape Seed Extracts Relax Blood Vessels Study Abstract We have shown in previous work that extracts of grape seeds (GSE) and skins, grape juice, and many ... wines exhibit endothelium-dependent relaxing (EDR) activity in vitro. This EDR activity involves endothelial nitric oxide (NO) release and subsequent increase in cyclic GMP levels in the vascular smooth muscle ... . The NO/cyclic GMP pathway is known to be involved in many cardiovascular-protective roles. The current study focuses on the isolation and identification of EDR-active compounds (procyanidins) from GSE ...

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