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3335. Cruciferous vegetable concentrates I3C and dim Supports healthy estrogen metabolism in men and women* Supports cellular health* Resveratrol, green tea extract, and quercetin CLEARANCE DISCO...
60 capsules $30.00 $18.00
1186. Nutrients for healthy hair, skin, collagen, and joints* Supports natural detoxification* Supports brain and immune function* 25% off in May!Sulfur Plus™ provides MSM sulfur and more to supports the respiratory system, GI tract, hair strength, and clearance of t...
100 capsules $19.00 $14.25
1191. Strengthen hair, skin, nails, bones* Support healthy sex drive and reproductive health* Enhance detoxification of heavy metals* Support healthy thyroid function* Improve sense of taste and digestion*Strengthener Plus™ provides nutrients for healthy body s...
100 capsules $16.00 $12.80
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Cruciferous vegetables have cancer preventing properties; overweight people are at greater cancer risk, but get extra protection from these vegeta...
... Flash plugin. This Week's Health Podcast Renewed scientific interest in the cancer preventing properties of cruciferous vegetables has gripped the scientific community in the past few years. When digested, cruciferous vegetables, produce a variety of sulfur rich metabolites. Indole-3-carbinol (I3C) and diindolylmethane (DIM) are especially important. I3C and DIM exhibit great potential for the prevention and part of the treatment for breast and prostate cancer. They may provide specific benefit in risk reduction for these cancers when associated with being overweight, which typically involves the most aggressive forms ...
DIM (diindolylmethane) is a derivative of I3C (indole-3-carbinol) which naturally come from cruciferous vegetables and are available in concentrat...
... Byron J. Richards, Board Certified Clinical Nutritionist DIM (diindolylmethane) is a derivative of I3C (indole-3-carbinol) which naturally come from cruciferous vegetables and are available in concentrated forms in dietary supplements. A new animal study shows that DIM can profoundly inhibit1 the spreading of breast cancer cells to the lungs. The researchers concluded "These results indicate that DIM has potential as an antimetastatic agent for the treatment of breast cancer." Numerous studies have shown that cruciferous vegetables, DIM, and I3C have significant protective effects on the female ...
Indole-3-carbinol and prostate cancer.
... Study Title: Indole-3-carbinol, DIM and Prostate Cancer Study Abstract Epidemiological and dietary studies have revealed an association between high dietary intake of cruciferous vegetables and decreased prostate cancer risk. Our studies have shown that indole-3-carbinol (I3C), a common phytochemical in cruciferous vegetables, and its in vivo dimeric product 3,3' diindolylmethane (DIM) upregulate the expression of phase I and phase II enzymes, suggesting increased capacity for detoxification and inhibition of carcinogens. Studies from our laboratory and others have found that I3C can induce G1 cell-cycle arrest and ...

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Oral Administration of 3,3'-Diindolylmethane Inhibits Lung Metastasis of 4T1 Murine Mammary Carcinoma Cells in BALB/c Mice
... Study Title: DIM Reduces Breast Cancer Spreading Study Abstract 3,3' diindolylmethane (DIM) is the major in vivo product of the acid-catalyzed oligomerization of indole-3-carbinol present in cruciferous vegetables, and it has been shown to exhibit anticancer properties. In this study, we assessed the effects of DIM on the metastasis of 4T1 mouse mammary carcinoma cells. In vitro culture studies showed that DIM dose-dependently inhibited the migration, invasion, and adhesion of 4T1 cells at concentrations of 0 – 10 µmol/L without attendant changes in cell viability. ...
Broccoli-derived phytochemicals indole-3-carbinol and 3,3'-diindolylmethane exerts concentration-dependent pleiotropic effects on prostate ca...
... Study Title: I3C and DIM Inhibit Insulin-Like Growth Factor-1 Study Abstract In the present studies, we utilized prostate cancer cell culture models to elucidate the mechanisms of action of broccoli-derived phytochemicals 3,3' diindolylmethane (DIM) and indole-3-carbinol (I3C). We found DIM and I3C at 1-5 µM inhibited androgen and estrogen-mediated pathways and induced xenobiotic metabolism pathway. By contrast, DIM and I3C induced cyclin inhibitors, indicators of stress/DNA damage, only at 25 µM. We also demonstrated that an inhibitory effect of DIM and I3C on ...
Indole-3-carbinol and prostate cancer.
... Study Title: Indole-3-carbinol, DIM and Prostate Cancer Study Abstract Epidemiological and dietary studies have revealed an association between high dietary intake of cruciferous vegetables and decreased prostate cancer risk. Our studies have shown that indole-3-carbinol (I3C), a common phytochemical in cruciferous vegetables, and its in vivo dimeric product 3,3' diindolylmethane (DIM) upregulate the expression of phase I and phase II enzymes, suggesting increased capacity for detoxification and inhibition of carcinogens. Studies from our laboratory and others have found that I3C can induce G1 cell-cycle arrest and ...

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Products

Showing 3 of 3
3335. Cruciferous vegetable concentrates I3C and dim Supports healthy estrogen metabolism in men and women* Supports cellular health* Resveratrol, green tea extract, and quercetin CLEARANCE DISCO...
60 capsules $30.00 $18.00
1186. Nutrients for healthy hair, skin, collagen, and joints* Supports natural detoxification* Supports brain and immune function* 25% off in May!Sulfur Plus™ provides MSM sulfur and more to supports the respiratory system, GI tract, hair strength, and clearance of t...
100 capsules $19.00 $14.25
1191. Strengthen hair, skin, nails, bones* Support healthy sex drive and reproductive health* Enhance detoxification of heavy metals* Support healthy thyroid function* Improve sense of taste and digestion*Strengthener Plus™ provides nutrients for healthy body s...
100 capsules $16.00 $12.80

News

Showing 10 of 32 View all news results >
Cruciferous vegetables have cancer preventing properties; overweight people are at greater cancer risk, but get extra protection from these vegeta...
... Flash plugin. This Week's Health Podcast Renewed scientific interest in the cancer preventing properties of cruciferous vegetables has gripped the scientific community in the past few years. When digested, cruciferous vegetables, produce a variety of sulfur rich metabolites. Indole-3-carbinol (I3C) and diindolylmethane (DIM) are especially important. I3C and DIM exhibit great potential for the prevention and part of the treatment for breast and prostate cancer. They may provide specific benefit in risk reduction for these cancers when associated with being overweight, which typically involves the most aggressive forms ...
DIM (diindolylmethane) is a derivative of I3C (indole-3-carbinol) which naturally come from cruciferous vegetables and are available in concentrat...
... Byron J. Richards, Board Certified Clinical Nutritionist DIM (diindolylmethane) is a derivative of I3C (indole-3-carbinol) which naturally come from cruciferous vegetables and are available in concentrated forms in dietary supplements. A new animal study shows that DIM can profoundly inhibit1 the spreading of breast cancer cells to the lungs. The researchers concluded "These results indicate that DIM has potential as an antimetastatic agent for the treatment of breast cancer." Numerous studies have shown that cruciferous vegetables, DIM, and I3C have significant protective effects on the female ...
Indole-3-carbinol and prostate cancer.
... Study Title: Indole-3-carbinol, DIM and Prostate Cancer Study Abstract Epidemiological and dietary studies have revealed an association between high dietary intake of cruciferous vegetables and decreased prostate cancer risk. Our studies have shown that indole-3-carbinol (I3C), a common phytochemical in cruciferous vegetables, and its in vivo dimeric product 3,3' diindolylmethane (DIM) upregulate the expression of phase I and phase II enzymes, suggesting increased capacity for detoxification and inhibition of carcinogens. Studies from our laboratory and others have found that I3C can induce G1 cell-cycle arrest and ...
Cruciferous vegetables, I3C, DIM, ginseng, curcumin, lipoic acid, melatonin, and selenium all have something powerful in common. These are just so...
... Linda J. Dobberstein, Chiropractor, Board Certified in Clinical Nutrition Cruciferous vegetables, I3C, DIM, ginseng, curcumin, lipoic acid, melatonin, and selenium all have something powerful in common. These are just some of the potent compounds existing in our foods that help our body detoxify and protect it from harm. These compounds are known to help protect our body from Estrogen Disruptor Compounds (EDCs) and help with detoxification. Cruciferous vegetables, I3C, and DIM Cruciferous vegetables are legendary for reducing risks associated with xenoestrogens, ...
Minireview: modulation of hormone receptor signaling by dietary anticancer indoles.
... Study Title: I3C and DIM as Anticancer Nutrients Study Abstract Indole-3-carbinol and its diindole condensation product 3-3' diindolylmethane are dietary phytochemicals that have striking anticarcinogenic properties in human cancer cells. Molecular, cellular, physiological, and clinical studies have documented that both indole-3-carbinol and 3-3' diindolylmethane have potent endocrine modulating activities through a myriad of mechanisms. The focus of this review is to discuss the evidence that directly links the anticancer actions of these two indole compounds to the control of steroid receptor and growth factor receptor signaling. Study Information Firestone GL, Sundar ...
Over the past few decades, researchers have debated on diets and have tried to prove which type of diet works best for weight loss and weight mana...
... a half, mankind has gone through a massive change in environmental cues to light to the point of basically being plugged in 24/7. This artificial light permits activity and food intake to occur during the night time hours and extends activity into the late night, dim light hours. So not only do we have artificial light that can decrease circadian rhythm signals, but we also have the behaviors of eating and activity during the artificial light that may contribute to reduced circadian rhythm balance. Researchers suspect that this environmental factor of electricity ...
Precocious puberty is early puberty that starts before age 8 in girls or 9 in boys. It is an increasingly common problem due to many environmental...
... resiliency and endocrine dysfunction. Sweating with physical activity, sports, or infrared sauna therapy is another great way to help the body detoxify. Additional nutritional support for removal of endocrine disrupting compounds includes silymarin, magnesium, glycine, iodine, selenium, zinc, I3C and DIM. If there is a history of traumatic brain injury, even a mild concussion, provide your child the omega-3, DHA, grape seed extract, and magnesium for basic support. Children face enough challenges today without having to understand why their body looks so much ...
Prostate cancer is the most common cancer in men today. If you have a family history of this cancer, make sure to follow these tips which will red...
... /curcumin, ginger, holy basil, oregano oil and green tea extract. Low carbohydrate consumption was also helpful. Several other nutrients have been studied for prostate cancer treatment and prevention. These include silymarin, tocotrienols, resveratrol, and cruciferous vegetables with the active compounds DIM and I3C. The flavonoids fisetin and quercetin have several studies that demonstrate them as anti-prostate cancer agents. Fisetin and quercetin have been shown to augment cancer therapy and provide preventative support. Cellular studies show that fisetin and quercetin provide natural anti-androgenic effects in both castrate-resistant and ...
Yale researchers have determined that men who eat half a cup of broccoli or cauliflower per week are half as likely to develop the deadly form of ...
... . As a person chews broccoli or cauliflower an enzyme within the vegetables activates the glucosinate called glucobassicin, producing the biologically active compound Indole-3-carbinol or I3C (also called indole-3-glucosinolate). I3C is broken down by stomach acid into various compounds, one of which is Diindolylmethane (DIM). Both I3C and DIM are available as dietary supplements, wherein one capsule provides far more of the active components of cruciferous vegetables than a half cup serving. This is great news for people who don't eat as much of these veggies as they should or ...
The phenomenon of increased breast tissue in men known as "gynecomastia" has risen considerably in the last few decades. It is becoming ...
... can be taken to reduce the exposure and to detoxify these compounds in men,women and children. In-depth information may be found in the article, Endocrine Disruptor Compounds and Natural Solutions. Critical compounds to incorporate for essential detoxification include indole-3-carbinol (I3C), diindolymethane (DIM), selenium, NAC, silymarin, MSM sulfur, and R-alpha lipoic acid. Make sure to include a diet rich in cabbage, broccoli, onions, radish, asparagus, etc. to help the daily work of detoxification. Testosterone production may be naturally ...

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Oral Administration of 3,3'-Diindolylmethane Inhibits Lung Metastasis of 4T1 Murine Mammary Carcinoma Cells in BALB/c Mice
... Study Title: DIM Reduces Breast Cancer Spreading Study Abstract 3,3' diindolylmethane (DIM) is the major in vivo product of the acid-catalyzed oligomerization of indole-3-carbinol present in cruciferous vegetables, and it has been shown to exhibit anticancer properties. In this study, we assessed the effects of DIM on the metastasis of 4T1 mouse mammary carcinoma cells. In vitro culture studies showed that DIM dose-dependently inhibited the migration, invasion, and adhesion of 4T1 cells at concentrations of 0 – 10 µmol/L without attendant changes in cell viability. ...
Broccoli-derived phytochemicals indole-3-carbinol and 3,3'-diindolylmethane exerts concentration-dependent pleiotropic effects on prostate ca...
... Study Title: I3C and DIM Inhibit Insulin-Like Growth Factor-1 Study Abstract In the present studies, we utilized prostate cancer cell culture models to elucidate the mechanisms of action of broccoli-derived phytochemicals 3,3' diindolylmethane (DIM) and indole-3-carbinol (I3C). We found DIM and I3C at 1-5 µM inhibited androgen and estrogen-mediated pathways and induced xenobiotic metabolism pathway. By contrast, DIM and I3C induced cyclin inhibitors, indicators of stress/DNA damage, only at 25 µM. We also demonstrated that an inhibitory effect of DIM and I3C on ...
Indole-3-carbinol and prostate cancer.
... Study Title: Indole-3-carbinol, DIM and Prostate Cancer Study Abstract Epidemiological and dietary studies have revealed an association between high dietary intake of cruciferous vegetables and decreased prostate cancer risk. Our studies have shown that indole-3-carbinol (I3C), a common phytochemical in cruciferous vegetables, and its in vivo dimeric product 3,3' diindolylmethane (DIM) upregulate the expression of phase I and phase II enzymes, suggesting increased capacity for detoxification and inhibition of carcinogens. Studies from our laboratory and others have found that I3C can induce G1 cell-cycle arrest and ...
Acute dim light at night increases body mass, alters metabolism, and shifts core body temperature circadian rhythms.
... Study Title: Acute dim light at night increases body mass, alters metabolism, and shifts core body temperature Study Abstract The circadian system is primarily entrained by the ambient light environment and is fundamentally linked to metabolism. Mounting evidence suggests a causal relationship among aberrant light exposure, shift work, and metabolic disease. Previous research has demonstrated deleterious metabolic phenotypes elicited by chronic( 4 weeks) exposure to dim light at night (DLAN)( 5 lux). However, the metabolic effects of short-term( Study Information Borniger JC, ...
Minireview: modulation of hormone receptor signaling by dietary anticancer indoles.
... Study Title: I3C and DIM as Anticancer Nutrients Study Abstract Indole-3-carbinol and its diindole condensation product 3-3' diindolylmethane are dietary phytochemicals that have striking anticarcinogenic properties in human cancer cells. Molecular, cellular, physiological, and clinical studies have documented that both indole-3-carbinol and 3-3' diindolylmethane have potent endocrine modulating activities through a myriad of mechanisms. The focus of this review is to discuss the evidence that directly links the anticancer actions of these two indole compounds to the control of steroid receptor and growth factor receptor signaling. Study Information Firestone GL, Sundar ...
Cruciferous Vegetables and Human Cancer Risk: Epidemiologic Evidence and Mechanistic Basis
... the protective effects may be influenced by individual genetic variation (polymorphisms) in the metabolism and elimination of isothiocyanates from the body. Cooking procedures also affect the bioavailability and intake of glucosinolates and their derivatives. Supplementation with I3C or the related dimer 3,3 ′-diindolylmethane (DIM) alters urinary estrogen metabolite profiles in women, but the effects of I3C and DIM on breast cancer risk are not known. Small preliminary trials in humans suggest that I3C supplementation may be beneficial in treating conditions related to human papilloma virus infection, such as cervical ...
Decreased melatonin secretion is associated with increased intestinal permeability and marker of endotoxemia in alcoholics
... factor in actively drinking alcoholics for gut leakiness and endotoxemia. We studied 20 subjects with alcohol use disorder (AD) and 17 healthy controls (HC, 6 day workers, 11 night workers). Subjects wore a wrist actiwatch for 7 days and underwent a 24-h dim light phase assessment and urine collection for intestinal permeability. The AD group had significantly less total sleep time and increased fragmentation of sleep (P Study Information Decreased melatonin secretion is associated with increased intestinal permeability and marker of endotoxemia in alcoholics Am J Physiol Gastrointest Liver Physiol ...
Plasticity of circadian clocks and consequences for metabolism.
... environmental cycles, including continuous exposure to light, affect the neuronal organization of the central circadian pacemaker in the suprachiasmatic nucleus (SCN), its waveform and amplitude of the rhythm in electrical activity. Moreover, repeated exposure to a shifted light cycle or the application of dim light at night are environmental cues that cause a change in SCN function. The effects on the SCN waveform are the result of changes in synchronization among the SCN's neuronal cell population, which lead consistently to metabolic disturbances. Furthermore, we discuss the effects of sleep ...
Acute sleep deprivation in healthy young men: Impact on population diversity and function of circulating neutrophils.
... after 8h regular sleep. We found that neutrophil counts were elevated after nocturnal wakefulness (2.0 0.2 10(9 )/ l vs. 2.6 0.2 10(9 )/ l, sleep vs. TSD, respectively) and the population contained more immature CD16(dim)/CD62L(bright) cells (0.11 0.040 10(9 )/ l [5.5 1.1%] vs. 0.26 0.020 10(9 )/ l [9.9 1.4%]). As the rise in numbers of circulating mature CD16(bright ...
The bright-nights and dim-days of the urban photoperiod: Implications for circadian rhythmicity, metabolism and obesity.
... Study Title: Implications for circadian rhythmicity, metabolism and obesity.Study Abstract Artificial light decreases the amplitude of daily rhythms in human lifestyle principally by permitting activity and food intake to occur during hours of darkness, and allowing day-time activity to occur in dim light, indoors. Endogenous circadian timing mechanisms that oscillate with a period of 24 h have evolved to ensure physiology is synchronized with the daily variations in light, food, and social cues of the environment. Artificial light affects the synchronization between these oscillators, and metabolic disruption may ...

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