The Blood Sugar Hormone Adiponectin is Linked to Your Circadian Clock

A detailed analysis of biological clocking genes¹ has shown that adiponectin Protein hormone that modulates metabolism including glucose and fatty acid catabolism. High levels are associated with low body fat. function is in sync with 24-hour patterns.  The data also showed that fasting causes the adiponectin Protein hormone that modulates metabolism including glucose and fatty acid catabolism. High levels are associated with low body fat. -relating timing to fast forward, whereas a high fat diet causes adiponectin Protein hormone that modulates metabolism including glucose and fatty acid catabolism. High levels are associated with low body fat. -related timing to enter jet lag.

Many people know that on some days their energy is in gear and clicking along and on other days their body feels more like molasses, a struggle to stay in motion.  These are examples of good timing and bad timing, regardless of the reason why.

Leptin is the commander in chief of all hormones and one of its main timing rhythms is on a 24-hour cycle wherein leptin levels are highest at midnight (meaning don’t eat food and prepare other hormones for sleep-related timing release).

In health, leptin and adiponectin Protein hormone that modulates metabolism including glucose and fatty acid catabolism. High levels are associated with low body fat. levels rise together as a team.  During weight gain, leptin levels rise excessively in the blood and do not enter the brain properly (causing leptin resistance and food cravings any time, especially at night).  The excess leptin in the blood causes adiponectin Protein hormone that modulates metabolism including glucose and fatty acid catabolism. High levels are associated with low body fat. to fall, resulting in insulin resistance and the risk for developing type II diabetes.

In addition to these general patterns and relationships of leptin and adiponectin Protein hormone that modulates metabolism including glucose and fatty acid catabolism. High levels are associated with low body fat. this new study indicates that the precise timing of adiponectin Protein hormone that modulates metabolism including glucose and fatty acid catabolism. High levels are associated with low body fat. can be thrown off, especially by over-consuming food.  The researchers also showed that bad timing caused gene related defects in adiponectin Protein hormone that modulates metabolism including glucose and fatty acid catabolism. High levels are associated with low body fat. receptors, interfering with the healthy processing of blood sugar.

It is interesting that fasting fast-forwards adiponectin Protein hormone that modulates metabolism including glucose and fatty acid catabolism. High levels are associated with low body fat. timing, a feature that may be useful in that a one-day fast will often clear the feeling of jet lag many people have from eating too much.  However, continued fasting for any length of time beyond 24 hours is very likely to induce the leptin-starvation response as well as disrupt the 24-hour rhythm just as much as overeating.

Managing adiponectin Protein hormone that modulates metabolism including glucose and fatty acid catabolism. High levels are associated with low body fat. well is the single most important hormone for preventing insulin resistance and type II diabetes.  The most basic way to do this is to follow the Five Rules of the Leptin Diet.