Leptin, Obesity, and Prostate Cancer

Tuesday, August 18, 2009 - Byron Richards, CCN

Duke University researchers have demonstrated that obesity in and of itself is a risk factor for aggressive prostate cancer.  The study involved 1415 men who had undergone radical prostatectomy as prostate cancer treatment (about 50/50 white and black men).  Race was not a factor in who was likely to continue disease progression based on the prostate cancer spreading aggressively, but obesity was.

Obesity is associated with the problem of leptin resistance, meaning too much leptin in the blood.  In turn, elevated leptin levels cause testosterone levels to drop, and low testosterone is also associated with aggressive prostate cancer.  Elevated leptin levels also cause adiponectin levels to drop resulting in a rise in blood sugar, insulin resistance, and confused IGF1 – additional factors that favor cancer growth. 

To make matters worse, extra pounds of fat send out inappropriate inflammatory signals such as IL6 and overheat the fundamental inflammatory gene signal known as NF-kappaB.

Simply put, lose weight if you want to reduce your risk of aggressive prostate cancer.

Related Entries: Prostate Cancer & the Androgen Receptor – A Clearer Picture of the Problem
Another Study Linking Obesity to Aggressive Prostate Cancer

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