How Fish Oil Rescues Metabolism from Obesity

Friday, February 13, 2009  -  Byron Richards, CCN

DHA Docosahexaenoic acid Essential omega 3 fatty acid integral to the health of all cell membranes, nerve and brain function. Must be gotten through the diet via cold water oceanic fish or some very limited plant sources or taken as a supplement. in particular, and fish oil in general, have been shown to have a powerful influence on the health and well being of your stored fat, as well as other aspects of metabolism such as insulin resistance.  In a new study working with the obese leptin-lacking mice1, researchers demonstrated the precise novel ways in which fish oil can protect against obesity, even in an animal that has no choice but to become obese.

The fish oil raised the level of adiponectin Protein hormone that modulates metabolism including glucose and fatty acid catabolism. High levels are associated with low body fat. in the white adipose tissue, which helps to calm down inflammation within stored fat.  Adiponectin also prevents insulin resistance and diabetes by improving how your liver can process sugar – which was demonstrated in this study.

Collectively, these benefits resulted in a decline of excess fat building up in the liver – preventing the very serious metabolic problem of fatty liver known as NASH (nonalcoholic steatohepatitis).  It is important to understand that this protection is occurring in an animal that literally has no choice but to become diseased from obesity and fish oil is stopping the process of disease progression.  This is a rather amazing study.

Additionally, the researchers discovered that fish oil was further metabolized into novel metabolic signaling compounds called protectins and resolvins, which were involved in many of the protective benefits of the omega-3 fatty acids.  This is an interesting new area of research.

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Referenced Studies:
  1. ^ Fish Oil, Obesity, Insulin Resistance, and Fatty Liver  Federation of the American Societies for Experimental Biology Journal.  Ana González-Périz, Raquel Horrillo, Natàlia Ferré, Karsten Gronert, Baiyan Dong, Eva Morán-Salvador, Esther Titos, Marcos Martínez-Clemente, Marta López-Parra, Vicente Arroyo, and Joan Clària .

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