Grape Seed Extract Lowers White Adipose Tissue Inflammation

One of the most devastating health aspects of being overweight is the change in immune system status within white adipose tissue fat stores.  There is a major shift of macrophages into the white adipose tissue which act in a highly inflammatory manner to alter the function of stored fat so that it becomes metabolically incompetent as well as directly adding to the overall inflammatory burden of one’s body.  This is why obesity is associated with more prevalence and earlier onset of any of the diseases of aging (cancer, heart disease, Alzheimer’s, etc).  A new study shows that grape seed extract¹ can turn down the inflammatory signals and consequent free radical damage from these white adipose tissue macrophages.

Of particular importance is the finding that grape seed extract can go to the gene-regulating source of the inflammation which is known as NF-kappaB Protein complex that controls DNA transcription and is involved with cellular responses to stress, cytokines, free radicals, UV radiation, oxidized LDL, and infections. .  Nutrients that show an ability to support healthy regulation of NF-kappaB Protein complex that controls DNA transcription and is involved with cellular responses to stress, cytokines, free radicals, UV radiation, oxidized LDL, and infections. , which is the brain of every cell’s stress response, show that the nutrient is significantly relieving the condition of cellular stress that otherwise wreaks havoc with human health.